Results 121 to 130 of about 188,104 (310)

Initial mutations direct alternative pathways of protein evolution [PDF]

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
core   +1 more source

Modelling Geomorphic Systems: Landscape Evolution [PDF]

, 2016
Landscape evolution models (LEMs) present the geomorphologist with a means of investigating how landscapes evolve in response to external forcings, such as climate and tectonics, as well as internal process laws.
Valters, Declan
core   +4 more sources

Geographic Patterns of Intra‐ and Interspecific Diversity of Riverine Fish Species in the Italian Northern Apennines and Ligurian Alps

Ecology and Evolution
Understanding the intricate dynamics of biodiversity within and across riverine ecosystems, influenced by geological history and environmental factors, is crucial for effective conservation and management strategies.
Dominik Kirschner, Gabrielle Vance, Virginie Marques, Monika Goralczyk, Alice Valentini, Xiaowei Zhang, Sean D. Willett, Florian Altermatt, Loïc Pellissier   +8 more
doaj   +1 more source

The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa

South African Journal of Science
In his 1925 paper describing the Taung Child fossil, Dart makes various assertions about the landscape around Taung, inferring past climate dynamics, and the role these factors play in the evolution of our early prehuman relatives.
Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering   +3 more
doaj   +1 more source

The role of landscape evolution in the genetic diversification of a stream fish Sarcocheilichthys parvus from Southern China. [PDF]

Front Genet, 2022
Li M, Yang X, Ni X, Fu C.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Modeling the evolution of natural cliffs subject to weathering. 1, Limit analysis approach [PDF]

, 2011
Retrogressive landsliding evolution of natural slopes subjected to weathering has been modeled by assuming Mohr-Coulomb material behavior and by using an analytical method.
G. B. Crosta, Crosta, Giovanni B., Utili, Stefano, S. Utili   +3 more
core   +1 more source

Hollows on Mercury: Creation and Analysis of a Global Reference Catalog With Deep Learning

Journal of Geophysical Research: Machine Learning and Computation
Hollows are geologically young depressions on Mercury, most likely associated with the loss of volatile species. The distribution and morphometric properties of hollows provide information about the overall volatile budget of Mercury's (shallow ...
Valentin T. Bickel, Ariel N. Deutsch, David T. Blewett   +2 more
doaj   +1 more source

Landscape evolution under the southern Laurentide Ice Sheet. [PDF]

Sci Adv, 2021
Naylor S, Wickert AD, Edmonds DA, Yanites BJ.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source