Results 141 to 150 of about 188,104 (310)

Climate‐Driven Topographic Asymmetry Enhanced by Glaciers: Implications for Drainage Reorganization in Glacial Landscapes

Geophysical Research Letters
Climate contrasts across drainage divides, such as orographic precipitation, are ubiquitous in mountain ranges, and as a result, mountain topography is often asymmetric.
Jingtao Lai, Kimberly Huppert
doaj   +1 more source

Author Correction: Dating the landscape evolution around the Chauvet-Pont d'Arc cave. [PDF]

Sci Rep, 2021
Genuite K, Delannoy JJ, Bahain JJ, Gresse M, Jaillet S, Philippe A, Pons-Branchu E, Revil A, Voinchet P.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi‐Century Erosion and Landscape Evolution of Ephemeral Catchments in Response to Sub‐Daily Rainfall Distribution Changes

Geophysical Research Letters
Changes in the properties of rainfall distributions at sub‐daily scales are key to assessing soil erosion rates under climate transition. However, such changes are difficult to detect and model, especially over landscape evolution timescales.
Yuval Shmilovitz, Matthew W. Rossi, Gregory E. Tucker   +2 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Forms of Emergence and the Evolution of Economic Landscapes [PDF]

Over the past two decades, the notion of ÔemergenceÕ has attracted increasing attention and controversy across the social sciences, as par of a growing interest in the applicability of complexity theory to socio-economic-political systems.
Peter Sunley, Ron Martin
core  

The Lasting Legacy of Megaflood Boulder Deposition in Mountain Rivers

Geophysical Research Letters
Infrequent, large‐magnitude discharge (>106 m3/s) outburst floods—megafloods—can play a major role in landscape evolution. Prehistoric glacial lake outburst megafloods transported and deposited large boulders (≥4 m), yet few studies consider their ...
S. M. Morey, C. M. Shobe, K. W. Huntington, K. A. Lang, A. G. Johnson, A. R. Duvall   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Landscape Evolution and Simulation of Rural Settlements around Wetland Park Based on MCCA Model and Landscape Theory: A Case Study of Chaohu Peninsula, China. [PDF]

Int J Environ Res Public Health, 2021
Fan X, Luo W, Yu H, Rong Y, Gu X, Zheng Y, Ou S, Tiando DS, Zhang Q, Tang G, Li J.   +10 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source