Results 151 to 160 of about 188,104 (310)
Landscape Economics : The Road Ahead [PDF]
The aims of this paper are to delineate some important topics in landscape economics, and also to take stock of the works and debates presented during the life of the CEEP project (from the first meeting in Angers (2006) , to the present one in Vienna ...
Robert Lifran
core
Contested Landscapes of Renewable Energies : Spatial Justice for Democratic Landscape [PDF]
, 2015 As a contribution to the discussion about landscape democracy, I propose to observe some contested landscapes of renewable energy and the local protest against them to understand whether they can provide some information on what a democratic energy ...
FERRARIO, VIVIANA
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Scenario thinking in landscape architecture education [PDF]
, 2019 The contribution presents the experience of the Final Master Studio in ‘Landscape Architecture and Infrastructures’ carried out in the last seven years at the Architecture Department of the University of Ferrara, Italy.
Gianni Lobosco
core
Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumours. [PDF]
Gut, 2021 Young K +23 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Optimising the spatial pattern of landscape revegetation [PDF]
The spatial pattern of landscape reconstruction makes a substantial difference to environmental outcomes. We develop a spatially explicit bio-economic model that optimises the reconstruction of a heavily cleared landscape through revegetation.
Pannell, David J. +4 more
core +1 more source