Results 151 to 160 of about 3,704,485 (249)

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Quaternary landscape evolution of Apennines peri-Adriatic belt: Insights into climate and tectonics from the fluvial record. [PDF]

Sci Adv
Ruscitto V, Delchiaro M, Richard M, Iacobucci G, Piacentini D, Troiani F, Seta MD.   +6 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Predicting the preservation of buried ore deposits using deep-time landscape evolution modeling. [PDF]

Sci Adv
Tu A, Zahirovic S, Polanco S, Boone SC, Boyd M, Mallard C, Restrepo P, Ibrahim Y, Mahoney L, Salles T, McInnes B, Farahbakhsh E, Kohlmann F, Seton M, Müller DR.   +14 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Complex Adaptations and the Evolution of Evolvability

, 2005
Complex Adaptations and the Evolution of Evolvability +representation problem: "evolvability critically depends on the way genetic variation maps onto phenotypic variation" +Evidence that phenotypic variation is under genetic control: canalization ...
Altenberg, Lee, Wagner, Gunter P.
core  

Editorial: Landscape evolution of the tropical regions: Dates, rates and beyond

Frontiers in Earth Science, 2022
Fabiano N. Pupim, Cécile Gautheron, Jean-Jacques Braun, Adolfo Quesada-Román, Sophie Cornu   +4 more
doaj   +1 more source

The Role of Tumor-Infiltrating B Lymphocytes in Colorectal Cancer Patients: A Systematic Review of Immune Landscape Evolution. [PDF]

Cancers (Basel)
Fagarasan G, Fagarasan V, Bintintan VV, Dindelegan GC.   +3 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Editorial: Continental Basin and Orogenic Processes: Tectonic Deformation and Associated Landscape and Environmental Evolution

Frontiers in Earth Science, 2022
Xuhua Shi, Xuhua Shi, Xuhua Shi, Hanlin Chen, Hanlin Chen, Rong Yang, Rong Yang, Huiping Zhang, Xiaoping Yuan   +8 more
doaj   +1 more source