Results 161 to 170 of about 188,104 (310)
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Acta Agronómica, 2009 Este trabalho teve como objetivo avaliar o geoprocessamento aplicado na identificação e localização potencial de conflitos de uso de 1592 ha em áreas de preservação permanentes (APPs) da microbacia do Córrego Monte Belo - Botucatu (SP, Brasil) (22° 45’ a
Campos Sérgio +4 more
doaj
Regional uniqueness of tree species composition and response to forest loss and climate change
Nature CommunicationsThe conservation and restoration of forest ecosystems require detailed knowledge of the native plant compositions. Here, we map global forest tree composition and assess the impacts of historical forest cover loss and climate change on trees.
Nina van Tiel +10 more
doaj +1 more source
A wind-albedo-wind feedback driven by landscape evolution. [PDF]
Nat Commun, 2020 Abell JT +8 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
About Cultural Landscape or the Landscape on our doorstep [PDF]
, 2019 Analysis of the evolution of cultural landscape studies in order to demonstrate how also ordinary rural landscape have valuable resources for their regeneration and, at the same time, conservation.
matteo dario paolucci
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Integrated land use modelling of agri-environmental measures to maintain biodiversity at landscape level [PDF]
Integrated land use models (ILM) are increasingly applied tools for the joint assessment of complex economic-environmental farming system interactions.
Schauppenlehner, Thomas +2 more
core +1 more source