Results 131 to 140 of about 188,104 (310)

Death perception: envisioning a cemetery landscape for the 21st century [PDF]

, 2009
This practicum, "Death Perception: Envisioning a cemetery landscape for the 21st century", is a proposal for an alternative cemetery landscape, responding to changes in Western culture. An investigation into the historical, sociological and psychological
Sawatzky, Erin Leanne
core  

Coupled influence of tectonics, climate, and surface processes on landscape evolution in southwestern North America. [PDF]

Nat Commun, 2022
Bahadori A, Holt WE, Feng R, Austermann J, Loughney KM, Salles T, Moresi L, Beucher R, Lu N, Flesch LM, Calvelage CM, Rasbury ET, Davis DM, Potochnik AR, Ward WB, Hatton K, Haq SSB, Smiley TM, Wooton KM, Badgley C.   +19 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Landscape Evolution and It's Impact of Ecosystem Service Value of the Wuhan City, China. [PDF]

Int J Environ Res Public Health, 2021
Chen R, Huang C.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Cultural Landscape & Heritage Paradox; Protection and Development of the Dutch Archeological-Historical Landscape and its European Dimension [PDF]

, 2010
To what extent can we know past and mainly invisible landscapes, and how we can use this still hidden knowledge for actual sustainable management of landscape’s cultural and historical values.
Kars, H., Wijnen, M., Bloemers, J.H.F., Valk, A.J.J., van der   +3 more
core  

Dating the landscape evolution around the Chauvet-Pont d'Arc cave. [PDF]

Sci Rep, 2021
Genuite K, Delannoy JJ, Bahain JJ, Gresse M, Jaillet S, Philippe A, Pons-Branchu E, Revil A, Voinchet P.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Holocene landscape evolution and its interaction with human activities in the southern piedmont of Taihang Mountain, Central China. [PDF]

Front Plant Sci, 2022
Zhang X, Yang S, Lu P, Li Y, Chen P, Xia Z.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source