Results 71 to 80 of about 952,563 (300)
Environmental DNA Epigenetics Accurately Predicts the Age of Cultured Fish Larvae
Ecology and EvolutionWhile acquiring age information is crucial for efficient stock management and biodiversity conservation, traditional aging methods fail to offer a universal, non‐invasive, and precise way of estimating a wild animal's age. DNA methylation from tissue DNA
Eliot Ruiz +7 more
doaj +1 more source
An evolutionary model for simple ecosystems
, 1999 In this review some simple models of asexual populations evolving on smooth landscapes are studied. The basic model is based on a cellular automaton, which is analyzed here in the spatial mean-field limit.
Bagnoli, Franco, Bezzi, Michele
core +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Structurally constrained protein evolution: results from a lattice simulation
, 2000 We simulate the evolution of a protein-like sequence subject to point mutations, imposing conservation of the ground state, thermodynamic stability and fast folding. Our model is aimed at describing neutral evolution of natural proteins.
Bastolla, Ugo +2 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Labyrinthic granular landscapes
, 2001 We have numerically studied a model of granular landscape eroded by wind. We show the appearance of labyrinthic patterns when the wind orientation turns by $90^\circ$. The occurence of such structures are discussed. Morever, we introduce the density $n_k$
D. Goossens +7 more
core +1 more source
Dynamic fitness landscapes: Expansions for small mutation rates [PDF]
, 2000 We study the evolution of asexual microorganisms with small mutation rate in fluctuating environments, and develop techniques that allow us to expand the formal solution of the evolution equations to first order in the mutation rate.
Demetrius +14 more
core +3 more sources
MOLECULAR EVOLUTION OVER THE MUTATIONAL LANDSCAPE [PDF]
Evolution, 1984 A common observation in phylogenetic comparisons of the amino acid sequences of a particular protein is that the rate of evolution of the protein is nearly constant over extended periods of time. This constancy was first noticed by Zuckerkandl and Pauling (1965) and prompted them to call the amino acid substitution process a "molecular evolutionary ...
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source