Results 71 to 80 of about 188,104 (310)

The Reservoir Age Effect Varies With the Mobilization of Pre-Aged Organic Carbon in a High-Altitude Central Asian Catchment

Frontiers in Earth Science, 2021
Lake sediments provide excellent archives to study past environmental and hydrological changes at high temporal resolution. However, their utility is often restricted by chronological uncertainties due to the “reservoir age effect” (RAE), a phenomenon ...
Natalie Schroeter, Jens Mingram, Julia Kalanke, Stefan Lauterbach, Stefan Lauterbach, Rik Tjallingii, Valérie F. Schwab, Gerd Gleixner   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Landscape Evolution [PDF]

, 2019
r.sim.terrain is a short-term landscape evolution model that simulates topographic change for both steady state and dynamic flow regimes across a range of spatial ...
Payam Tabrizian, Helena Mitasova, Vaclav Petras, Brendan Harmon, Anna Petrasova   +4 more
core   +1 more source

Protein Structural Information and Evolutionary Landscape by In Vitro Evolution [PDF]

, 2020
Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades.
Lisi, Simonetta, Cattaneo, Antonino, Lisi S., Cattaneo A., De Los Rios, Paolo, Pastore A., Fantini, Marco, Pastore, Annalisa, De Los Rios P., Fantini M.   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Landscape Evolution Runs [PDF]

, 2019
Simulations runs of this landscape evolution ...
Payam Tabrizian, Vaclav Petras, Helena Mitasova, Brendan Harmon, Anna Petrasova   +4 more
core   +1 more source

Comparing Watershed‐Based eDNA Sampling and Camera Trapping for Assessing Mammal Diversity in North‐Western Bhutan

Environmental DNA
The ability of environmental DNA (eDNA) to provide rapid assessments of mammal taxa composition at the watershed scale can make it an efficient survey method on large‐scale landscapes, complementing camera traps.
Karma Sherub, Sarah Thurnheer, Martina Lüthi, Virginie Marques, Arnaud Lyet, Tashi Dhendup, Lungten Dorji, Camille Albouy, Loïc Pellissier   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source