Results 51 to 60 of about 335,836 (263)
Controlling brain dynamics: Landscape and transition path for working memory.
PLoS Computational Biology, 2023 Understanding the underlying dynamical mechanisms of the brain and controlling it is a crucial issue in brain science. The energy landscape and transition path approach provides a possible route to address these challenges. Here, taking working memory as
Leijun Ye, Jianfeng Feng, Chunhe Li
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Functional characterization of theZEB2regulatory landscape [PDF]
Human Molecular Genetics, 2018 Zinc finger E-box-binding homeobox 2 (ZEB2) is a key developmental regulator of the central nervous system (CNS). Although the transcriptional regulation of ZEB2 is essential for CNS development, the elements that regulate ZEB2 expression have yet to be identified.
Reut Bar Yaacov +5 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
An intelligent LED landscape lighting system
ITM Web of Conferences, 2018 This paper introduces a kind of landscape lighting control system is composed of the monitoring center and intelligent controller. The intelligent controller realizes the control of the LED landscape lamp, and the monitoring center realizes the ...
Zhang Lei, Fang Jie, Yu Ping
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On simplified global nonlinear function for fitness landscape: a case study of inverse protein folding. [PDF]
PLoS ONE, 2014 The construction of fitness landscape has broad implication in understanding molecular evolution, cellular epigenetic state, and protein structures. We studied the problem of constructing fitness landscape of inverse protein folding or protein design ...
Yun Xu, Changyu Hu, Yang Dai, Jie Liang
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The functional proteome landscape of Escherichia coli
Nature, 2020 Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3-6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar phenotypic changes across several perturbations (chemical, environmental or genetic) when knocked out7-
André Mateus +10 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
THE FUNCTION OF PLANTATION FORESTRY IN LANDSCAPE CONNECTIVITY
Applied Ecology and Environmental Research, 2016 Plantation forestry has been widely used for industrial purposes, creating vast extensions of culture forests. Although these plantations have a primary economic goal, they may indirectly serve other functions, such as landscape connectivity. Eucalypts are among the main plantation species used worldwide.
Cabarga Varona, Alejandro +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revitalizing the Art of Persian Miniature Painting in the Urban Landscape and the Function of Citizens' Cultural Capital [PDF]
پیکرهIntroduction: The urban landscape, which includes a view with physical, functional, and cultural-semantic characteristics, provides a suitable ground for the representation of urban art and plays an important function in revitalizing Persian miniature ...
Zohreh Taher, Zahra Rahbarnia
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