Results 71 to 80 of about 335,836 (263)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Missing Set: How Landscape Acts in The Cherry Orchard

Studies in 20th & 21st Century Literature, 2000
Why is the cherry orchard almost entirely absent from the stage? How does this absent landscape function dramatically? Chekhov's own garden expertise supports a study of the way that landscape in this play—its presence at once pervasive and virtual—both ...
Ann Leone
doaj   +1 more source

Localization of quantum states and landscape functions [PDF]

Proceedings of the American Mathematical Society, 2017
Eigenfunctions in inhomogeneous media can have strong localization properties. Filoche and Mayboroda showed that the function u u
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differentiation of landscape structures in space and time – basis of landscape planning documents

Littera Scripta, 2011
The industrial revolution and subsequent industrialization of society represented a fundamental change to the landscape of the Czech Republic or, more precisely, the whole of Central Europe. These changes are reflected in the change of landscape structure
Dagmar Stejskalová, Lenka Tlapáková, Jana Podhrázská, Petr Karásek
doaj  

Spatiotemporal evolution of the rural-urban interface and its effects on ecological landscape structure and function: A case study of Nanjing, China

Ecological Indicators
Understanding the evolution of the rural-urban interface (RUI) and its dynamic ecological consequences is of great theoretical and practical significance for urban-rural integration and management.
Hui Cao, Pingxing Li, Jianglong Chen, Cheng Chen, Weixuan Song   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development of the Tourist Function Within Areas of Lower Silesian Landscape Parks

Studia Ekonomiczne i Regionalne, 2017
Subject and purpose of work: The aim of the study was to present the development of the tourist function in the areas of Lower Silesian landscape parks. The subject of the study were the communes associated with Lower Silesian landscape parks.
Uglis Jarosław, Jęczmyk Anna
doaj   +1 more source