Results 121 to 130 of about 1,387,202 (292)

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The expanding global genomics landscape: Converging priorities from national genomics programs

The global landscape of health genomics is expanding rapidly, with an increasing number of national and international initiatives, many of which are targeted toward accelerating the clinical implementation of genomic technologies and services in the ...
Haas, MA, Green, ED, Lundgren, B, Annan, RB, Howley, C, Boughtwood, T, Scott, RH, Al Muftah, WA, Tan, P, North, KN, Stark, Z   +10 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Genomic landscape of endometrial polyps

Genome Medicine
Endometrial polyps are common, localized overgrowths of endometrial glands and stroma that protrude into the uterine cavity. These tumor-like lesions can cause symptoms like abnormal uterine bleeding and infertility, and they may undergo malignant transformation. The etiology of endometrial polyps remains largely unknown.Here, we conducted whole-genome
Reinikka, Siiri, Mehine, Miika, von Nandelstadh, Pernilla, Ahvenainen, Terhi, Khamaiseh, Sara, Nousiainen, Susanna, Jokinen, Vilja, Pasanen, Annukka, Bützow, Ralf, Sarvilinna, Nanna, Pitkänen, Esa, Vahteristo, Pia   +11 more
openaire   +3 more sources

Genomic Landscape of Appendiceal Neoplasms

JCO Precision Oncology, 2018
Purpose Appendiceal neoplasms are heterogeneous and are often treated with chemotherapy similarly to colorectal cancer (CRC). Genomic profiling was performed on 703 appendiceal cancer specimens to compare the mutation profiles of appendiceal subtypes to CRC and other cancers, with the ultimate aim to identify potential biomarkers and novel therapeutic ...
Ang, Celina, Shen, John, Hardy-Abeloos, Camille, Huang, Justin, Ross, Jeffrey, Miller, Vincent, Jacobs, Miriam, Chen, Ingrid, Xu, David, Ali, Siraj, Lowy, Andrew, Fanta, Paul, Ideker, Trey, Millis, Sherri, Harismendy, Olivier, Baumgartner, Joel   +15 more
openaire   +5 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Science for action at the local landscape scale

, 2013
For landscape ecology to produce knowledge relevant to society, it must include considerations of human culture and behavior, extending beyond the natural sciences to synthesize with many other disciplines.
Liu, Jianguo, Albert, C., Nassauer, JI, Liu, J. G., Swaffield, Simon, Swaffield, SR, Opdam, Paul, McAlpine, C, Castella, J-C, Sheppard, S, Sheppard, Stephen, Nassauer, Joan Iverson, Nassauer, J. I., McAlpine, Clive, McAlpine, C., Bentrup, G, Wang, Z, Albert, C, Wang, Zhifang, Opdam, P, Opdam, P., Castella, Jean-Christophe, Swaffield, S., Liu, J, Bentrup, G., Albert, Christian, Wang, Z. F., Bentrup, Gary, Sheppard, S.   +28 more
core   +1 more source

Using landscape genomics to assess local adaptation of fruit trees to current and future climatic conditions

Fruit Research
Local adaptation has been proven to be common in plants and extensively studied, from increasing plant yields to predicting species responses to the future changing climate.
Xu Zhang, Quan Jiang, Yufang Shen, Hengchang Wang, Xiaohong Yao   +4 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source