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Genomic and Epigenomic Landscape in Meningioma
Neurosurgery Clinics of North America, 2016Meningiomas are the most common primary intracranial neoplasms in adults. Despite their prevalence, their biologic underpinnings remain incompletely described. The recent application of unbiased next-generation sequencing and epigenomic approaches has implicated a new array of candidate biomarkers and oncogenic drivers.
Wenya Linda, Bi +4 more
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The Genomic and Epigenomic Landscapes of AML
Seminars in Hematology, 2014A progressively better understanding of the genetic and epigenetic abnormalities underlying acute myeloid leukemia has changed clinical practice and affected the outcome of thousands of patients. Over the past decades, approaches focused on cloning, sequencing, and functional characterization of one or a few genes were the preferred (and the only ...
Luca Mazzarella +4 more
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The genomic landscape of advanced cancer
Nature Cancer, 2020Despite recent advances in cancer treatment, metastasis and therapy resistance remain among the major causes of cancer-related deaths worldwide. A recent pan-cancer study provides a comprehensive molecular profile of advanced and post-therapy tumors, integrating whole-genome and transcriptomic analysis with clinical outcomes.
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Exploring the Landscape of the Genome
2010Genome browsers are powerful tools for biologists - offering fundamental information on genes, regulatory elements, genomic variants, genome structure, and evolution. The comprehensive range of information presented in tools such as the UCSC genome browser and Ensembl enables integrated queries of data that are otherwise reserved to the most skilled ...
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The genomic landscape of nasopharyngeal carcinoma
Nature Genetics, 2014Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as well as SNP array analysis.
De-Chen, Lin +20 more
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Genomic Landscape of Waldenström Macroglobulinemia
Hematology/Oncology Clinics of North America, 2018Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM). Common mutations include MYD88 (95%-97%), as well as CXCR4 (30%-40%), ARID1A (17%), and CD79B (8%-15%), which are typically found in MYD88-mutated patients.
Steven P, Treon +5 more
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The Genomic Landscape of Sporadic Prolactinomas
Endocrine Pathology, 2019Somatic GNAS and USP8 mutations have been implicated in sporadic somatotrophinomas and corticotrophinomas, respectively. However, no genes are known to be recurrently mutated in sporadic prolactinomas. The prevalence of copy number variants (CNV), which is emerging as a mechanism of tumorigenesis in sporadic pituitary adenomas in general, is also ...
Sunita M. C. De Sousa +12 more
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Genomic landscape of retinoblastoma
Clinical & Experimental Ophthalmology, 2014Victor M, Villegas +4 more
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An update on the immune landscape in lung and head and neck cancers
Ca-A Cancer Journal for Clinicians, 2020Jennifer W Carlisle +2 more
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