Results 21 to 30 of about 1,387,202 (292)
The genomic landscapes of inflammation [PDF]
Genes & Development, 2011 Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site.
Natoli G, Ghisletti S, Barozzi I
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Cancer Genome Landscapes [PDF]
Science, 2013 Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of “hills” (genes altered infrequently). To date, these studies have revealed
Bert, Vogelstein +5 more
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Genomic Landscape of Hodgkin Lymphoma [PDF]
Cancers, 2021 Background: Hodgkin lymphoma (HL) is predominantly composed of reactive, non-neoplastic cells surrounding scarcely distributed tumor cells, that is, so-called Hodgkin and Reed-Sternberg (HRS) or lymphocyte predominant (LP) cells. This scarcity impeded the analysis of the tumor cell genomes for a long time, but recently developed methods (especially ...
Magdalena M. Brune +4 more
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Special Issue “Latest Review Papers in Molecular Genetics and Genomics 2023”
, 2023 In the rapidly evolving landscape of molecular genetics and genomics, this Special Issue brings together a collection of insightful review articles that delve into the forefront of scientific exploration [...
Apostolos Zaravinos
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The genomic landscape of phaeochromocytoma [PDF]
The Journal of Pathology, 2015 AbstractPhaeochromocytomas (PCCs) and paragangliomas (PGLs) are rare neural crest‐derived tumours originating from adrenal chromaffin cells or extra‐adrenal sympathetic and parasympathetic tissues. More than a third of PCC/PGL cases are associated with heritable syndromes involving 13 or more known genes.
Aidan, Flynn +14 more
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The genomic landscape of prostate cancer [PDF]
Frontiers in Endocrinology, 2012 Prostate cancer is a common malignancy in men, with a markedly variable clinical course. Somatic alterations in DNA drive the growth of prostate cancers and may underlie the behavior of aggressive versus indolent tumors. The accelerating application of genomic technologies over the last two decades has identified mutations that drive prostate cancer ...
Sylvan eBaca +6 more
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Frontiers in Genetics, 2020 Massive parallel sequencing (MPS) is revolutionizing the field of molecular ecology by allowing us to understand better the evolutionary history of populations and species, and to detect genomic regions that could be under selection.
Jonás A. Aguirre-Liguori +4 more
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Frontiers in Ecology and Evolution, 2022 Understanding the role of natural selection in the evolution of wild populations is challenging due to the spatial complexity of natural systems. The richest diversity of freshwater fishes in the world is found in the Amazon Basin, a system where marked ...
Abbie C. Hay +5 more
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The Genomic Landscape of Prostate Cancer [PDF]
International Journal of Molecular Sciences, 2013 By the age of 80, approximately 80% of men will manifest some cancerous cells within their prostate, indicating that prostate cancer constitutes a major health burden. While this disease is clinically insignificant in most men, it can become lethal in others.
Spans, Lien +7 more
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Evolutionary Applications, 2022 Identifying areas of high evolutionary potential is a judicious strategy for developing conservation priorities in the face of environmental change.
Allison H. Alvarado +6 more
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