Results 101 to 110 of about 151,140 (266)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

The heterogeneous cellular landscape of atherosclerosis

Atherosclerosis, 2023
Single cell technologies, lineage tracing mouse models and advanced imaging techniques unequivocally improved the resolution of the cellular landscape of atherosclerosis. Although the discovery of the heterogeneous nature of the cellular plaque architecture has undoubtedly improved our understanding of the specific cellular states in atherosclerosis ...
Bonacina, Fabrizia, di Costanzo, Alessia, Genkel, Vadim, Kong, Xiang Yi, Kroon, Jeffrey, Stimjanin, Ena, Tsiantoulas, Dimitrios, Grootaert, Mandy O. J.   +7 more
openaire   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

The history of natural resources management among the Luo society of Western Kenya: Socio-ecological parameters of landscape heterogeneity

International Journal of Geoheritage and Parks
In this study, we thoroughly explore the complexities of land resource management in Western Kenya's Nyanza Province, focusing on the evolution of land use patterns in Kajulu location, which was formerly a native reserve. Spanning pre-colonial, colonial,
Delphine Birman
doaj   +1 more source

Studying pollen representation of vegetation and plant richness from Pampean coastal dunes (Argentina, South America): exploring from local to landscape quantitative linkages

Boletín de la Sociedad Argentina de Botánica
Background and aims: Studying plant dynamics through past pollen records may contribute to a better understanding of long-term changes in plant communities.
Carolina Vásquez , Gonzalo Sottile, Victor Merino-Campos, Silvina Stutz   +3 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Increasing landscape heterogeneity as a win-win solution to manage trade-offs in biological control of crop and woodland pests. [PDF]

Sci Rep, 2023
Tortosa A, Giffard B, Sirami C, Larrieu L, Ladet S, Vialatte A.   +5 more
europepmc   +1 more source

Engagement Patterns with an AI Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, Accepted Article.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed‐methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Seasonal resource selection of a grassland bird in a dynamic landscape: Importance of a heterogeneous landscape

Ecosphere
Habitat loss and fragmentation are a growing threat to wildlife, and a better understanding of these landscape processes is needed to mitigate their effects on species populations.
Sprih Harsh, Robert C. Lonsinger, Hilary R. Kauth, Andrew J. Gregory   +3 more
doaj   +1 more source