Results 101 to 110 of about 439,531 (308)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Participatory design and use of a simplified landscape in a simulation model for mitigating land use conflict in Northern Thailand highlands [PDF]
, 2009 Landscape modelling integrating spatial information in Geographic Information Systems has been widely used to represent knowledge and support decision-making in the field of natural resource management.
Dumrongrojwatthana, P. +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
LandUnderstanding vegetation heterogeneity dynamics is crucial for assessing ecosystem resilience, biodiversity patterns, and the impacts of environmental changes on landscape functions.
Ehsan Rahimi, Chuleui Jung
doaj +1 more source
Tree-Ring Variability of Larch (Larix Sibirica Ledeb.) in Different Landscape Positions of the Terekhol Depression, Tuva, Russia in the 20th Century [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2011 Dendroecological approach was applied to study of fundamental problem in landscape science - a relationship between pattern and functioning of landscape.
Ekaterina P. Kuznetsova +1 more
doaj
Modelling Spatial Regimes in Farms Technologies [PDF]
, 2017 We exploit the information derived from geographical coordinates to endogenously identify spatial regimes in technologies that are the result of a variety of complex, dynamic interactions among site-specific environmental variables and farmer decision ...
Benedetti, Roberto +2 more
core +3 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source