Results 81 to 90 of about 439,531 (308)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Regional Patterns of Ecosystem Services in Cultural Landscapes

Land, 2016
European agricultural landscapes have been shaped by humans to produce marketable private goods such as food, feed, fiber and timber. Land-use intensification to increase provisioning services in such productive landscapes alters the capacity of ...
Andrea Früh-Müller, Stefan Hotes, Lutz Breuer, Volkmar Wolters, Thomas Koellner   +4 more
doaj   +1 more source

Landscape heterogeneity influences on sheep habits under extensive grazing management in Southern Patagonia [PDF]

, 2015
In Southern Patagonia, continuous grazing with fixed stocking rates in large paddocks prevails over grazing systems subjected to regular evaluations and rotational rests.
Peri, Pablo Luis
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Gradient surface metrics of ecosystem structural diversity and their relationship with productivity across macrosystems

Ecosphere
Structural diversity—the volume and physical arrangement of vegetation within the three‐dimensional (3D) space of ecosystems—is a predictor of ecosystem function that can be measured at large scales with remote sensing. However, the landscape composition
Elizabeth A. LaRue, Kylie M. Rezendes, Dennis H. Choi, Jianmin Wang, Anna G. Downing, Songlin Fei, Brady S. Hardiman   +6 more
doaj   +1 more source

Oak heterogeneity shaping arthropod diversity and ecological dynamics in Boumezrane forest (Souk Ahras, Algeria) [PDF]

Journal of Insect Biodiversity and Systematics
The Boumezrane Forest in northeastern Algeria is a biodiversity hotspot characterized by a mosaic of oak species and varied habitats. This study examines how habitat heterogeneity influences arthropod diversity across five forest habitats: Cork Oak, Zeen
Abdallah Aouadi, Lamia Boutabia, Fethi Ayaichia, Dounia Zeghouma, Mohcen Menaa, Mohamed Cherif Maazi, Badreddine Bouacha, Salaheddine Doumandji, Salah Telailia   +8 more
doaj   +1 more source

Introducing Preference Heterogeneity into a Monocentric Urban Model: an Agent-Based Land Market Model [PDF]

, 2008
This paper presents an agent-based urban land market model. We first replace the centralized price determination mechanism of the monocentric urban market model with a series of bilateral trades distributed in space and time.
Filatova, Tatiana, Parker, Dawn C., Veen, Anne van der   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Arctic greening associated with lengthening growing seasons in Northern Alaska

Environmental Research Letters, 2019
Many studies have reported that the Arctic is greening; however, we lack an understanding of the detailed patterns and processes that are leading to this observed greening.
Kyle A Arndt, Maria J Santos, Susan Ustin, Scott J Davidson, Doug Stow, Walter C Oechel, Thao T P Tran, Brian Graybill, Donatella Zona   +8 more
doaj   +1 more source

Um paradigma alternativo para o ordenamento do território e o turismo em paisagens costeiras: as métricas espaciais como indicadores para ordenamento e o turismo em paisagens costeiras [PDF]

, 2018
Coastal urbanization dynamics in the Algarve are intimately related with tourism, which dominates the regional economy. We present part of the results of a research project in the coastal landscapes of Algarve, focusing on land use and land change ...
Botequilha-Leitão, André, Diáz-Varela, Emilio   +1 more
core   +2 more sources