Results 91 to 100 of about 439,531 (308)

The heterogeneous landscape of ALK negative ALCL

Oncotarget, 2017
Anaplastic Large Cell Lymphoma (ALCL) is a clinical and biological heterogeneous disease including systemic ALK positive and ALK negative entities. Whereas ALK positive ALCLs are molecularly characterized and readily diagnosed, specific immunophenotypic or genetic features to define ALK negative ALCL are missing, and their distinction from other T-cell
Mereu, Elisabetta, Pellegrino, Elisa, ScarfÃ2, Irene, Inghirami, Giorgio, Piva, Roberto   +4 more
openaire   +5 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Landscape metrics and indices : an overview of their use in landscape research [PDF]

, 2009
The aim of this overview paper is to analyze the use of various landscape metrics and landscape indices for the characterization of landscape structure and various processes at both landscape and ecosystem level.
Antrop, Marc, Mander, Ülo, Marja, Riho, Roosaare, Jüri, Uuemaa, Evelin   +4 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

METODOLOGIE DI ANALISI DEL PAESAGGIO NELLA VALUTAZIONE DELL’ETEROGENEITÁ STRUTTURALE NEI REEF A VERMETI [PDF]

, 2012
Landscape ecology is a discipline that uses many indices to describe environmental dynamics as a function of structural patch organization. Application of landscape ecology methods can be a way to evaluate heterogeneity and fragmentation of a habitat ...
CHEMELLO, Renato, Chemello, S, Graziano, M, Zarzana, C   +3 more
core  

Optimization Aspects of Carcinogenesis

, 2009
Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process.
Brutovsky, B., Horvath, D.
core   +3 more sources

Imaging Oxygen Distribution in Marine Sediments. The Importance of Bioturbation and Sediment Heterogeneity [PDF]

, 2008
The influence of sediment oxygen heterogeneity, due to bioturbation, on diffusive oxygen flux was investigated. Laboratory experiments were carried out with 3 macrobenthic species presenting different bioturbation behaviour patterns:the polychaetes ...
AK Hannides, AL Freestone, B Thamdrup, BB Jorgensen, BJ Cardinale, DC Rhoads, E Kristensen, E Kristensen, E Kristensen, E Kristensen, E Kristensen, E Michaud, E Michaud, EJ Gustafson, ER Trueman, F François, F François, F Gilbert, F Mermillod-Blondin, F Talin, F. Gilbert, H Kautsky, H Li, H Rasmussen, J Tardy, J. C. Poggiale, JC Poggiale, JT Davey, L. Pischedda, M Gérino, M Gérino, ML Cadenasso, NP Revsbech, NP Revsbech, P Berg, P Duttilleul, P. Cuny, PVR Snelgrove, QZ Zhu, RA Berner, RC Aller, RC Aller, RC Aller, RL Foster-Smith, RN Glud, RV O’Neill, S Garrigues, S Hulth, SC Dufour, TH Pearson   +49 more
core   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Determinants of species richness patterns in the Netherlands across multiple taxonomic groups [PDF]

, 2009
We examined the species richness patterns of five different species groups (mosses, reptiles and amphibians, grasshoppers and crickets, dragonflies, and hoverflies) in the Netherlands (41,500 km2) using sampling units of 5 × 5 km. We compared the spatial
Barendrecht, A., Kleukers, R., Schouten, M.A., Verweij, P.A.   +3 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source