Results 51 to 60 of about 151,140 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The heterogeneous landscape of ALK negative ALCL

Oncotarget, 2017
Anaplastic Large Cell Lymphoma (ALCL) is a clinical and biological heterogeneous disease including systemic ALK positive and ALK negative entities. Whereas ALK positive ALCLs are molecularly characterized and readily diagnosed, specific immunophenotypic or genetic features to define ALK negative ALCL are missing, and their distinction from other T-cell
Mereu, Elisabetta, Pellegrino, Elisa, Inghirami, Giorgio, Piva, Roberto, Scarfo, Irene   +4 more
openaire   +5 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Assessing the impact of urban greenspace on physical health: An empirical study from Southwest China

Frontiers in Public Health, 2023
IntroductionAs the world becomes increasingly urbanized and human-nature contact declines, urban greenspace's impact on human health has garnered growing interest across academic disciplines. Various definitions and multiple indicators of greenspace have
Barnabas C. Seyler, Barnabas C. Seyler, Han Luo, Han Luo, Xiuli Wang, Sophia Zuoqiu, Yao Xie, Yao Xie, Yuan Wang   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Landscape-Clustering Zoning Strategy to Map Multi-Crops in Fragmented Cropland Regions Using Sentinel-2 and Sentinel-1 Imagery with Feature Selection

Agriculture
Crop mapping using remote sensing is a reliable and efficient approach to obtaining timely and accurate crop information. Previous studies predominantly focused on large-scale regions characterized by simple cropping structures.
Guanru Fang, Chen Wang, Taifeng Dong, Ziming Wang, Cheng Cai, Jiaqi Chen, Mengyu Liu, Huanxue Zhang   +7 more
doaj   +1 more source

Using a simulation analysis to evaluate the impact of crop mapping error on crop area estimation from stratified sampling

International Journal of Digital Earth, 2019
To analyze the efficiency of area estimations (i.e. estimation accuracy and variation of estimation) impacted by crop mapping error, we simulated error at eight levels for thematic maps using a stratified sampling estimation methodology. The results show
Peijun Sun, Russell G. Congalton, Yaozhong Pan   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Spatiotemporal organization of cryptic North American Culex species along an urbanization gradient

Ecological Solutions and Evidence, 2023
Landscape heterogeneity creates diverse habitat and resources for mosquito vectors of disease. A consequence may be varied distribution and abundance of vector species over space and time dependent on niche requirements.
Arielle Arsenault‐Benoit, Megan L. Fritz   +1 more
doaj   +1 more source