Results 51 to 60 of about 151,713 (266)

A Systematic Review of Within-Population Variation in the Size of Home Range Across Ungulates: What Do We Know After 50 Years of Telemetry Studies?

Frontiers in Ecology and Evolution, 2021
Studying the factors determining the sizes of home ranges, based on body mass, feeding style, and sociality level, is a long-standing goal at the intersection of ecology and evolution. Yet, how species-specific life history traits interact with different
Juliette Seigle-Ferrand, Kamal Atmeh, Jean-Michel Gaillard, Victor Ronget, Nicolas Morellet, Mathieu Garel, Anne Loison, Glenn Yannic   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Underpinning upscaling of nature-based solutions (NBS) in freshwaters using ecological principles and existing data

Frontiers in Sustainability
Global ambitions to restore degraded ecosystems, together with the recent adoption of the EU restoration law, demand an urgent and substantial upscaling of restoration efforts.
Nikolai Friberg, Jóna Ólavsdóttir, Georgina L. Brennan   +2 more
doaj   +1 more source

Seasonality buffers carbon budget variability across heterogeneous landscapes in Alaskan Arctic tundra

Environmental Research Letters, 2021
Arctic tundra exhibits large landscape heterogeneity in microtopography, hydrology, and active layer depth. While many carbon flux measurements and experiments are done at or below the mesoscale (⩽1 km), modern ecosystem carbon modeling is often done at ...
Josh Hashemi, Donatella Zona, Kyle A Arndt, Aram Kalhori, Walter C Oechel   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Gradient surface metrics of ecosystem structural diversity and their relationship with productivity across macrosystems

Ecosphere
Structural diversity—the volume and physical arrangement of vegetation within the three‐dimensional (3D) space of ecosystems—is a predictor of ecosystem function that can be measured at large scales with remote sensing. However, the landscape composition
Elizabeth A. LaRue, Kylie M. Rezendes, Dennis H. Choi, Jianmin Wang, Anna G. Downing, Songlin Fei, Brady S. Hardiman   +6 more
doaj   +1 more source

Habitat Structure Outweighs Monastic Legacy in Shaping Bird Assemblages

Animals
Sacred natural sites are often considered potential refugia for biodiversity in human-dominated landscapes, but their effects can be confounded by present-day habitat structure.
Łukasz Jankowiak, Kinga Piórkowska, Michał Polakowski, Sebastian Michałowski, Michał Szkudlarek   +4 more
doaj   +1 more source