Results 91 to 100 of about 5,327,669 (304)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Effects of landscape pattern change on waterbird diversity in Xianghai Nature Reserve

Open Geosciences
In order to study the change of landscape pattern and its impact on waterbird diversity in Xianghai Nature Reserve, this article analyzes the changing landscape pattern of the reserve from 2014 to 2017 at the landscape and type level. Pearson correlation
Zhao Yuelan, Liu Jiping, Li Huifen, Zhao Dandan   +3 more
doaj   +1 more source

Landscape Analysis and Assessment of Ecosystem Stability Based on Land Use and Multitemporal Remote Sensing: A Case Study of the Zhungeer Open-Pit Coal Mining Area

Remote Sensing
Intensive mining activities in the Zhungeer open-pit coal mining area of China have resulted in drastic changes to land use and landscape patterns, severely affecting the ecological quality and stability of the region.
Yinli Bi, Tao Liu, Yanru Pei, Xiao Wang, Xinpeng Du   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Reconciling natural habitat size loss and quality enhancement: the dual effects of urbanization in China’s Loess Plateau

Environmental Research Letters
Amid accelerating urbanization and severe biodiversity loss in global drylands, reconciling urbanization with habitat conservation is crucial for sustainable development.
Siya Li, Qiulei Ji, Wei Liang, Tingting Wang, Wenbin Liu, Hong Wang, Yao Feng, Fen Gou, Zhenguo Wang, Fubao Sun   +9 more
doaj   +1 more source

Assessment of ecological values of greening landscape elements in the Great Hungarian Plain

Journal of Environmental Geography, 2017
The research examines the effects of agricultural subsidies on the landscape structure. According to the hypothesis, greening – which has been introduced as part of the European Union’s Common Agriculture Policy (EU CAP) reform –, if it is properly ...
Máté Klaudia
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Landscape Diversity Indexes Application for Agricultural Land Use Optimization

Procedia Technology, 2013
AbstractThe paper is focused on land use optimization using landscape metrics (landscape diversity indexes) in order to solve the urgent problem of biological and landscape diversity loss due to intensive agricultural activities. Besides the ecological and social values, more diverse ecosystems appear to be more productive and stable, than are less ...
Kuchma, Tetyana, Tarariko, Oleksandr, Syrotenko, Oleksandr   +2 more
openaire   +1 more source