Results 41 to 50 of about 5,495 (213)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Construction of urban wetland ecological landscape planning model based on MSPA analysis method

Journal of Environmental Engineering and Landscape Management, 2022
The traditional method does not accurately select the ecological landscape pattern index of urban wetland, which leads to the problems of low accuracy and long planning time, in order to solve this problem, an urban wetland ecological landscape planning
Shengnan Sun, Shan Li, Jiefang Tang, Jinle Su   +3 more
doaj   +1 more source

Perspective on the Refractive-Index Gas Metrology Data Landscape

Journal of Physical and Chemical Reference Data, 2021
The redefinition of the kelvin has increased focus on thermometry techniques that use the newly fixed value of the Boltzmann constant to realize thermodynamic temperature. One such technique that has advanced considerably in recent years is refractive-index gas thermometry.
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Systematic Environmental Impact Assessment for Non-natural Reserve Areas: A Case Study of the Chaishitan Water Conservancy Project on Land Use and Plant Diversity in Yunnan, China

Frontiers in Ecology and Evolution, 2017
Environmental impact assessment (EIA) before and after the establishment of a Water Conservancy Project (WCP) is of great theoretical and practical importance for assessing the effectiveness of ecological restoration efforts.
Zhi-Xin Zhu, Kun-Kun Zhao, Qin-Wen Lin, Salman Qureshi, Salman Qureshi, Salman Qureshi, Cynthia Ross Friedman, Guo-Yin Cai, Guo-Yin Cai, Hua-Feng Wang   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ecological Risk in the Mountainous Metropolis of Chongqing: Historical Assessment and Flows of SSPs-RCPs Scenarios

Shuitu Baochi Xuebao
[Objective] Chongqing is a mega-metropolis located in the southwestern hilly region. The rising population and extensive economic development have led to rapid urban landscape ascent and expansion, resulting in a dual urban-rural and 3D spatial structure
WEI Mengyu, BIAN Hongyan, GAO Jie, ZHANG Lujin, JIA Runxi, LI Haolin, WANG Linyong   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Pattern change and ecological risk analysis of Shilin World Geopark landscape

Frontiers in Ecology and Evolution
This study considered Shilin World Geopark as the research object and constructed a landscape ecological risk assessment model based on the landscape pattern index by using remote sensing image data during five periods between 2000 and 2020. In addition,
Yiqi Shi, Hongxia Gao, Shucheng Tan, Shucheng Tan, Hongfu Qin, Zhuang Tian, Jingxian Meng, Xin Zheng   +7 more
doaj   +1 more source