Results 61 to 70 of about 5,495 (213)
Constraints on the spectral index for the inflation models in the string landscape [PDF]
Physical Review D, 2007 We conjecture that the inflation models with trans-Planckian excursions in the field space should be in the swampland. We check this conjecture in a few examples and investigate the constraints on the spectral index for the slow-roll inflation model in string landscape where the variation of inflaton during the period of inflation is less than the ...
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2019 Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change ...
Junmei Kang +5 more
doaj +1 more source
Indexing the vulnerability of biotopes to landscape changes
Ecological Indicators, 2019 Abstract Biodiversity loss is one of the great challenges of our times, and it is primarily driven by losses of natural and semi-natural areas. To avoid further biodiversity losses, landscape planning and ecosystem management could benefit from a condensed measure that tracks regional and cumulative ecological degradation from past and ongoing ...
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A Study on Application of Landscape Diagnosis Index and Landscape Formation Plan of Rural Villages
Journal of Korean Society of Rural Planning, 2013 In this study, it propose what the landscape elements is to be improved urgently and how to improve landscape by reflecting the rural village characteristics away from the spatial integrated landscape planning. The study area for landscape research is selected as the 9 rural villages in Chungcheongbuk-do, and research is done by using village unit ...
Hee-Jung Song +3 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Remote SensingIntensive mining activities in the Zhungeer open-pit coal mining area of China have resulted in drastic changes to land use and landscape patterns, severely affecting the ecological quality and stability of the region.
Yinli Bi +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source