Results 71 to 80 of about 5,327,669 (304)
AgronomyThe accurate prediction of the spatial variability for soil water content (SWC) in farmland is essential for water resource management and sustainable agricultural development.
Weihao Yang +5 more
doaj +1 more source
, 2016 Researchers and planners worldwide have emphasized the need for a better planning in an urbanizing world. The expansion of urbanized areas has increased people's access to modern facilities and urban infrastructures but decreased the quality of life due ...
A. Gavrilidis +4 more
semanticscholar +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
THEORETICAL VIEW OF THE SHANNON INDEX IN THE EVALUATION OF LANDSCAPE DIVERSITY
, 2017 Shannon’s diversity index is frequently used in the determination of landscape diversity. Its indisputable advantage is a possibility to obtain numeric values that can subsequently be easily compared.
R. Dusek, Renata Popelková
semanticscholar +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2017 Environmental impact assessment (EIA) before and after the establishment of a Water Conservancy Project (WCP) is of great theoretical and practical importance for assessing the effectiveness of ecological restoration efforts.
Zhi-Xin Zhu +9 more
doaj +1 more source
Landscape Change Index as a Tool for Spatial Analysis
, 2017 This study analysed spatial and temporal changes in protected landscape of Ślęża Landscape Park in Poland, covering an area of 7724 ha. The main objective was to determine level of landscape change of the research area after Polish accession to European ...
P. Krajewski +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source