Results 41 to 50 of about 337,078 (312)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sustainable Landscape Management and Planning
, 2020 Dynamic changes of landscape structure affect the abundance and distribution of organisms. Currently, changing land-use is one of the major forces altering ecosystem services in landscapes globally. Human activities are transforming land at a faster rate
Ivo Machar
core +1 more source
Groundwater management in coastal areas through landscape scale planning: A systematic literature review [PDF]
, 2020 Groundwater is one of the main resources for social-ecological systems. As part of the total water cycle and deeply connected with land use, groundwater management faces many challenges, especially in coastal areas.
De Oliveira Galvao, Carlos +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Does landscape-scale conservation management enhance the provision of ecosystem services? [PDF]
, 2014 Biodiversity conservation approaches are increasingly being implemented at the landscape-scale to support the maintenance of metapopulations and metacommunities.
Newton, Adrian +3 more
core +1 more source
Specifying geospatial data product characteristics for forest and fuel management applications
Environmental Research Letters, 2022 One of the greatest challenges for land managers is to maintain a multitude of ecosystem services while reducing hazards posed by wildfires, insect outbreaks, and other disturbances accelerating due to climate change.
Arjan J H Meddens +5 more
doaj +1 more source
Land, 2023 The main goal of the study, based on historical-geographical research, was to reconstruct the history of an anthropogenically created cultural landscape on the southern edge of the Muránska Planina National Park in the Western Carpathians (Slovakia) as a
Bohuslava Gregorová +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Journal of Environmental Engineering and Landscape Management, 2013 Even when a Protected Area (PA) is adequately managed within its boundaries, its ecological functioning may be influenced by human activities in the surrounding landscape through a number of mechanisms.
Mattia Cai, Davide Pettenella
doaj +1 more source
Integrating stakeholder preferences into ecosystem services mapping in Yala wetland, Kenya
Ecosystems and People, 2022 Wetlands such as the Yala swamp in Kenya are among the most important and increasingly threatened ecosystems globally due to their ecological significance and complexity, and the importance of the ecosystem services (ES) they provide to wetland ...
Yvonne Wambui Githiora-Murimi +4 more
doaj +1 more source