Results 51 to 60 of about 337,078 (312)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Urban landscape ecology and its evaluation : a review [PDF]

open access: yes, 2009
Urban landscapes exhibit combinations of environmental features that are rarely encountered in non-urban settings resulting in habitat types, habitat associations and vegetation communities not found elsewhere.
Young, Christopher   +7 more
core  

Towards More Equitable Urban Greening: A Framework for Monitoring and Evaluating Co-Governance

open access: yesUrban Planning
Urban greening has grown in significance in Europe and worldwide as a presumed “public good” initiative, delivering a range of benefits for human health and wellbeing.
Eleanor Chapman   +4 more
doaj   +1 more source

Associations between landscape values, self-reported knowledge, and land-use: a public participation GIS assessment

open access: yesEcosystems and People, 2022
While previous socio-ecological systems research has shown relationships between local knowledge and the assignment of landscape values, the relationships between value assignment and more nuanced forms of local knowledge remain less understood.
Sara Zaman   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A study on Ecotect application of local climate at a residential area in Chuncheon, Korea

open access: yesJournal of Environmental Engineering and Landscape Management, 2015
The local climate data were investigated at a residential area in Chuncheon from May to October in 2013.In addition, the simulations were carried out by the Autodesk Ecotect Analysis tool. Site A had the lowest temperature in summer.
Qian Wu, Hyun-Kil Jo
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

The Future of Traditional Landscapes: Discussions and Visions

open access: yesLand, 2019
At the 2018 meeting of the Permanent European Conference for the Study of the Rural Landscape (PECSRL), that took place in Clermont-Ferrand and Mende in France, the Institute for Research on European Agricultural Landscapes e.V.
Hans Renes   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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