Results 51 to 60 of about 184,016 (242)

Pattern and process: the language of landscape ecology

Landscape Review, 1997
Landscape architecture and landscape ecology are fundamentally concerned with the connections between landscape pattern and ecological process. Landscape ecologists typically assume that process creates pattern; landscape architects address pattern with ...
Catherine Alington
doaj  

Integration of In-VEST Habitat Quality Model with Landscape Pattern Indices to Assess Habitat Fragmentation Under the Dynamic Development of Park City: Southwest China Case

Land
With rapid urbanization, the types of land in China’s cities are continuously evolving, irreversibly impacting the habitat patches within urban areas. However, the development of park cities has reversed this trend to some extent, particularly in Chengdu,
Rong Lin, Chris Zevenbergen, Jiahao Wang, Yixuan Li, Liyuan Qian   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Generative Landscape Elements: Paving patterns

International Journal for Research in Applied Science and Engineering Technology, 2023
Abstract: One of the basic works which is frequently done in any landscape project is designing a paving pattern. It sounds easy, but to derive a pattern with a set of design goals, requires various hit and trails to get into the final one. There are lot of parameters which we have to cover based on the requirements and context of the site. For Example,
Ar. Piyush Pant, Ar. Monica Sharma
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Grain size effect of landscape in Jiangxi Guanshan subtropical evergreen broad-leaved forest

Guangxi Zhiwu
Determining an appropriate grain size is crucial in landscape pattern analysis and ecological research. In order to gain deeper insights into the spatial diversity and dynamic characteristics of landscape pattern, based on the survey data of the 12 hm2 ...
RAN Huan1, LAN Yong2, DAI Yufeng2, XIONG Yong2, WEN Renquan1, SONG Qingni1, YANG Qingpei1, LIU Jun1*
doaj   +1 more source

Mountainous City Featured Landscape Planning Based on GIS-AHP Analytical Method

ISPRS International Journal of Geo-Information, 2020
In order to take full advantage of the landscape resources in the city’s featured landscape planning, and mutually integrate ecological green land with city space, this paper takes the mountainous city, Qianxi County, as the research subject to conduct ...
Yanlong Liu, Li Li
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source