Results 111 to 120 of about 437,940 (300)

Coupled InVEST–MGWR modeling to analyze the impacts of changing landscape patterns on habitat quality in the Fen River basin

open access: yesScientific Reports
The present study employed remote sensing images of the Fen River Basin from 2005, 2010, 2015, and 2020 as the primary data source. The software ENVI, ArcGIS, and Fragstats 4.2 were utilized to measure the landscape pattern index of the Fen River Basin ...
Juemei Wu, Yanjun Hou, Zheng Cui
doaj   +1 more source

Stage-Dependent Evolution of Floodplain Landscapes in the Lower Yellow River Under Dam Regulation

open access: yesLand
The floodplain landscape of the lower Yellow River is jointly shaped by natural water-sediment processes and human activities. With intensified regulation by large reservoirs and increasing human development intensity, the landscape pattern of the ...
Xiaohong Wei   +3 more
doaj   +1 more source

Enhancing urban analysis through lacunarity multiscale measurement [PDF]

open access: yes, 2005
Urban spatial configurations in most part of the developing countries showparticular urban forms associated with the more informal urban development ofthese areas.
Alves Junior, S, Barros Filho, M
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Landscape Ecological Integrity Assessment to Improve Protected Area Management of Forest Ecosystem

open access: yesEcologies
Understanding the ecological integrity of a protected area is a central topic for the management and conservation of these key areas. An ecological integrity framework based on a series of landscape ecology indices was developed to monitor and evaluate ...
Mingquan Yu, Yizhen Liu
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Optimization of PM2.5 Estimation Using Landscape Pattern Information and Land Use Regression Model in Zhejiang, China

open access: yesAtmosphere, 2018
The motivation of this paper is that the effect of landscape pattern information on the accuracy of particulate matter estimation is seldom reported. The landscape pattern indexes were incorporated in a land use regression (LUR) model to investigate the ...
Shan Yang   +4 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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