Results 91 to 100 of about 74,383 (294)
Spatial Gradient Effects of Landscape Pattern on Ecological Quality Along the Grand Canal
The Grand Canal serves as a vital water transportation route, a UNESCO World Cultural Heritage site, and an ecological corridor. It is currently undergoing coordinated transformation through infrastructure development, heritage preservation, and ...
Aibo Jin, Yonggeng Xiong
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Spatiotemporal analysis of Indian megacities
, 2008 Urbanization is arguably the most dramatic form of highly irreversible land transformation. While urbanization is a worldwide phenomenon, it is exceptionally dynamic in India, where unprecedented urban growth rates have occurred over the last 30 years ...
Taubenböck, Hannes +5 more
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Forest Fire Spread Hazard and Landscape Pattern Characteristics in the Mountainous District, Beijing
, 2023 Objective: This study established an index system for assessing forest fire spread hazards and conducted a forest fire spread hazard assessment in the mountainous district of Beijing (including Fangshan, Mentougou, Changping, Yanqing, Huairou, Miyun, and
Guanghui Lai +6 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Unsustainable human activities threaten the ecological security of arid and semi-arid watersheds. However, improving the connectivity of ecological networks can enhance ecosystem services and preserve biodiversity in these fragile environments.
Bojie Wang, Weichen Zhang, Yuyang Fan
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Construction and Optimization of Wetland Landscape Ecological Network in Dongying City, China
, 2022 Rapid urbanization has led to deteriorated wetland water quality, reduced biodiversity, and fragmented wetland landscapes, which seriously threaten the sustainable development of regional ecology.
Linzhe Yang +5 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Greenways as strategic landscape planning: theory and application
, 2002 Greenways are systems and/or networks of protected lands that are managed for multiple uses including: nature protection, biodiversity management, water resources, recreation, and cultural/historic resource protection.
Ahern, J.F.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source