Results 81 to 90 of about 74,383 (294)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Construction of surface hydrological linkage index based on landscape pattern and process

Meitan xuebao
Under the high-intensity disturbance of human activities such as resource development and land use, landscape patterns and topography are substantially altered, thereby influencing surface hydrological connectivity and processes among ecological units ...
Shaogang LEI, Chunhui HU, Haoyu SUN, Lixiang JIANG, Jianying ZHANG   +4 more
doaj   +1 more source

Optimization of landscape pattern in China Luojiang Xiaoxi basin based on landscape ecological risk assessment

, 2023
Multi-source ecological risks have induced many ecological pollution problems that cannot be ignored and seriously threaten regional ecological security.
Shaokun Li, Zhi Zhang, Xiaoqian Chen, Lei Wang, Shaojun Wang, Zhuangzhuang Wang, Wenxi He, Tianci Lei   +7 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Scaling Correction of Remotely Sensed Leaf Area Index for Farmland Landscape Pattern With Multitype Spatial Heterogeneities Using Fractal Dimension and Contextural Parameters

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2018
High-accuracy retrieval of the crop leaf area index (LAI) in farmlands via remote sensing is the premise of reflecting the true growth condition of the crop. This paper aimed at scaling correction of LAI retrieval and developed an LAI scaling transfer model for farmland landscape pattern with multitype spatial heterogeneities according to the multiple ...
Ling Wu, Xiangnan Liu, Qiming Qin, Bingyu Zhao, Yujia Ma, Mengxue Liu, Tian Jiang   +6 more
openaire   +2 more sources

Dynamic Changes Analysis of Dangshan Landscape Pattern

, 2011
The article takes 2 TM images as the data source, supported by the Fragstats 3.3 and the ENVI 4.7 softwares, two remote sensing images are classified by the support vector machine method, selects the number of patches (NP), edge density (ED), patches ...
Gang Fang, Qiang Zhao, Jian Yong Chen, Juan Yang, Hai Min Su   +4 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Morse Index Classification and Landscape of Kuramoto System for Hebbian-based Binary Pattern Recognition

This study examines the Kuramoto model with a Hebbian learning rule and second-order Fourier coupling for binary pattern recognition. The system stores memorized binary patterns as stable critical points, enabling it to identify the closest match to a defective input.
Zhao, Xiaoxue, Zhou, Xiang
openaire   +2 more sources

Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005)

, 2013
[cat] Utilitzem un conjunt de mètriques del paisatge per estudiar l'evolució a llarg termini seguida en una típica zona costanera del Mediterrani des de 1850 fins a 2005, que mostren una greu deterioració del medi ambient entre 1950 i 2005.
Marull, Joan, Pino i Vilalta, Joan, Parcerisas i Benedé, Lluís, 1978-, Coll, Francesc, Tello, Enric, Basnou, Corina   +5 more
core