Results 71 to 80 of about 16,161,426 (301)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Landscape Structure Changes Caused by Land Consolidation

Littera Scripta, 2010
Nowadays, what is discussed more and more is the quality of land consolidation and the related need of a standard process being established, but also quality indicators. One possibility to ”measure” land consolidation efficiency is to make the connection
Jan Váchal, Václav Mazín, Marie Trantinová, Radka Váchalová, Jana Moravcová, Monika Koupilová
doaj  

Relationship between microspatial population genetic structure and habitat heterogeneity in Pomatias elegans (O.F. Müller 1774) (Caenogastropoda, Pomatiasidae) [PDF]

, 2006
In the present study the population genetic structure of the terrestrial snail Pomatias elegans was related to habitat structure on a microspatial scale.
Pfenninger, Markus
core  

Statistical modeling of RNA structure profiling experiments enables parsimonious reconstruction of structure landscapes. [PDF]

, 2018
RNA plays key regulatory roles in diverse cellular processes, where its functionality often derives from folding into and converting between structures.
Aviran, Sharon, Li, Hua
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Understanding Landscape Structure Using Landscape Metrics

, 2013
Landscape metrics are important tools which are used to understand landscape structure and landscape changes. To use metrics, numeric data is obtained related to landscape structure. Numeric data is produced from satellite images and air photos. Also, landscape metrics are used as compatible with geographical information systems.
openaire   +4 more sources

Comparison of landscape changes in protected and unprotected sites on the outskirts of Prague metropolis (the Czech Republic), 1990–2006

Acta Universitatis Carolinae Geographica, 2016
The Czech landscapes have been shaped by many driving forces such as sub/urbanisation, construction of transport and logistics infrastructure, afforestation or agriculture extensification.
Kateřina Jačková, Tomáš Chuman, Dušan Romportl   +2 more
doaj   +1 more source