Results 71 to 80 of about 265,587 (266)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Structural Change in Romanian Land Use and Land Cover (1990–2018): A Multi-Index Analysis Integrating Kolmogorov Complexity, Fractal Analysis, and GLCM Texture Measures

Geomatics
Monitoring land use and land cover (LULC) transformations is essential for understanding socio-ecological dynamics. This study assesses structural shifts in Romania’s landscapes between 1990 and 2018 by integrating algorithmic complexity, fractal ...
Ion Andronache, Ana-Maria Ciobotaru
doaj   +1 more source

The Montérégie Connection: linking landscapes, biodiversity, and ecosystem services to improve decision making

Ecology and Society, 2015
To maximize specific ecosystem services (ES) such as food production, people alter landscape structure, i.e., the types of ecosystems present, their relative proportions, and their spatial arrangement across landscapes.
Matthew G. E. Mitchell, Elena M. Bennett, Andrew Gonzalez, Martin J. Lechowicz, Jeanine M. Rhemtulla, Jeffrey A. Cardille, Kees Vanderheyden, Geneviève Poirier-Ghys, Delphine Renard, Sylvestre Delmotte, Cécile H. Albert, Bronwyn Rayfield, Maria Dumitru, Hsin-Hui Huang, Martine Larouche, Kate N. Liss, Dorothy Y. Maguire, Kyle T. Martins, Marta Terrado, Carly Ziter, Lucie Taliana, Karine Dancose   +21 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Paikkatietoa ja muistitietoa yhdistämässä. Porin Pihlavan muistin paikkoja

J@rgonia, 2023
Yhdistämällä muisti- ja paikkatietoa voidaan tunnistaa ja vahvistaa tutkimuskohteena olevan alueen asukkaiden ja muiden sidosryhmien yhteisöllisiä merkityksenantoja. Tarkastelen Porin Pihlavan muistin paikkoja ja niihin kiinnittyviä muistoja, kokemuksia,
Virtanen, Katrina
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Land abandonment, landscape, and biodiversity: questioning the restorative character of the forest transition in the Mediterranean

Ecology and Society, 2015
The effects of land abandonment on biodiversity have received considerable attention by scholars, but results are far from conclusive. Different cultural traditions of scientists seem to underlie the contrasting ways in which land abandonment is ...
Iago Otero, Joan Marull, Enric Tello, Giovanna L. Diana, Manel Pons, Francesc Coll, Martí Boada   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Assessment of ecological values of greening landscape elements in the Great Hungarian Plain

Journal of Environmental Geography, 2017
The research examines the effects of agricultural subsidies on the landscape structure. According to the hypothesis, greening – which has been introduced as part of the European Union’s Common Agriculture Policy (EU CAP) reform –, if it is properly ...
Máté Klaudia
doaj   +1 more source