Results 81 to 90 of about 265,587 (266)

Structural Features of Cultural Landscape in the Karst Area (Landscape in Transition)

Acta Carsologica, 2016
Na območju krasa se je v dolgi zgodovinski kontinuiteti razvil svojevrsten krajinski tip, kar je pripisati raznovrstnim podnebnim, geomorfološkim, topografskim kot tudi družbeno-gospodarskim razmeram. To zvrst označuje velika tipološka raznolikost, ki sloni na avtentičnih značilnostih naravnega in kulturnega izvora, nastala pa je kot nasledek ...
Perica, Dražen, Aničić, Branka
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of Landscape Structure on Species Diversity

PLoS ONE, 2013
The effects of habitat fragmentation and their implications for biodiversity is a central issue in conservation biology which still lacks an overall comprehension. There is not yet a clear consensus on how to quantify fragmentation even though it is quite common to couple the effects of habitat loss with habitat fragmentation on biodiversity.
Paulo R A Campos, Alexandre Rosas, Viviane M de Oliveira, Marcelo A F Gomes   +3 more
openaire   +4 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Understanding Landscape Structure Using Landscape Metrics

, 2013
Landscape metrics are important tools which are used to understand landscape structure and landscape changes. To use metrics, numeric data is obtained related to landscape structure. Numeric data is produced from satellite images and air photos. Also, landscape metrics are used as compatible with geographical information systems.
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Landscape Structural Patterns and Soil–Water Loss in the Karst Critical Zone in Southwest China: Coupling Mechanisms, Regional Specificity, and Research Challenges

Land
Karst critical zones in Southwest China are highly vulnerable to soil–water loss because thin soils, exposed carbonate bedrock, well-developed epikarst, and strong surface–subsurface connectivity promote both surface erosion and subsurface leakage ...
Chenyi Zhu, Xiaoxi Lyu, Dongnan Wang, Jinglin Mo, Yunyu Huang, Mingyue Ma   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Examination of the Kastamonu City Center Ring Road in Terms of Spatial Fragmentation

Forestist
The holistic functioning of the green system is essential for the sustainability of living environments. Ring roads built to reduce density in urban transportation networks can create a barrier effect on urban habitats if not planned considering the ...
Gül Aslı Bozbay, Ayşe Nur Kaya
doaj   +1 more source