Results 81 to 90 of about 16,161,426 (301)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Landsharing for climat smart lanscapes in dry and humid tropical livestock areas [PDF]

, 2019
Livestock activities present large GHG emissions, especially in the Southern countries, but in the same time high potentialities for mitigation and adaptation. Promoting a transition to explore theses potentialities is a key challenge for CSA.
Assouma, Mohamed Habibou, Blanfort, Vincent, Plassin, Sophie, Poccard-Chapuis, René, Vayssières, Jonathan   +4 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Gradient surface metrics of ecosystem structural diversity and their relationship with productivity across macrosystems

Ecosphere
Structural diversity—the volume and physical arrangement of vegetation within the three‐dimensional (3D) space of ecosystems—is a predictor of ecosystem function that can be measured at large scales with remote sensing. However, the landscape composition
Elizabeth A. LaRue, Kylie M. Rezendes, Dennis H. Choi, Jianmin Wang, Anna G. Downing, Songlin Fei, Brady S. Hardiman   +6 more
doaj   +1 more source

Surprisingly Little Population Genetic Structure In A Fungus-Associated Beetle Despite Its Exploitation Of Multiple Hosts [PDF]

, 2013
In heterogeneous environments, landscape features directly affect the structure of genetic variation among populations by functioning as barriers to gene flow.
Brodie, E. D., III, Donald, H. M., Formica, Vincent A., Wood, Corlett W., , \u2708   +3 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Epigenetic Landscape of Interacting Cells: A Model Simulation for Developmental Process

, 2010
We propose a physical model for developmental process at cellular level to discuss the mechanism of epigenetic landscape. In our simplified model, a minimal model, the network of the interaction among cells generates the landscape epigenetically and the ...
Bar-Even, Eigen, Fersht, Forgacs, Gilbert, Gilbert, Huang, Kaneko, Lee, Lehman, Mayer-Kress, Melnick, Motoki Nakagawa, Newman, Osamu Narikiyo, Pál, Skar, Striedter, Waddington, Wolpert   +19 more
core   +1 more source

Fractal Profit Landscape of the Stock Market [PDF]

, 2012
We investigate the structure of the profit landscape obtained from the most basic, fluctuation based, trading strategy applied for the daily stock price data. The strategy is parameterized by only two variables, p and q. Stocks are sold and bought if the
Andreas Grönlund, AW Lo, B Mandelbrot, B Tóth, Beom Jun Kim, BG Malkiel, BM Barber, C-H Park, CH Yeung, E Weinberger, F Black, G Fusai, Guido Germano, Il Gu Yi, K Yamasaki, L Menkhoff, MHR Stanley, P Gopikrishnan, PSP Cowpertwait, R Sullivan, RL Axtell, RN Mantegna, S Schulmeister, W Schoutens, Y Baek   +24 more
core   +5 more sources

Landscape structure affects the provision of multiple ecosystem services

, 2016
Understanding how landscape structure, the composition and configuration of land use/land cover (LULC) types, affects the relative supply of ecosystem services (ES), is critical to improving landscape management.
T. Lamy, K. Liss, Andrew Gonzalez, E. Bennett   +3 more
semanticscholar   +1 more source