Results 91 to 100 of about 16,161,426 (301)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Potential Distribution and the Risks of Bactericera cockerelli and Its Associated Plant Pathogen Candidatus Liberibacter Solanacearum for Global Potato Production

open access: yesInsects, 2020
The tomato potato psyllid (TPP), Bactericera cockerelli, is a psyllid native to North America that has recently invaded New Zealand and Australia. The potential for economic losses accompanying invasions of TPP and its associated bacterial plant pathogen
Jing Wan   +3 more
doaj   +1 more source

Effects of random pinning on the potential energy landscape of a supercooled liquid

open access: yes, 2019
We use energy landscape methods to investigate the response of a supercooled liquid to random pinning. We classify the structural similarity of different energy minima using a measure of overlap.
de Souza, V. K.   +3 more
core   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Cross-Border Comparison of Non-Forest Woody Vegetation in the White Carpathians (Central Europe) Over Last 65 Years

open access: yesJournal of Landscape Ecology, 2019
Landscape structure is determined by human activities and natural processes. Despite both influences are described in many studies, there remains still question, how the landscape structure reflects the individual socio-economic predictors.
Demková Katarína   +2 more
doaj   +1 more source

Changes in the Secondary Landscape Structure in Hruby Jesenik Mountains (Czech Republic)

open access: yesJournal of Landscape Ecology, 2020
This study deals with the analysis of changes in the secondary landscape structure of the territory of the Jeseniky Mountains (Czech Republic) monitored in the years 1946, 1953, 1962, 2000, and 2016.
Dostal Adam, Machar Ivo, Mackovcin Peter
doaj   +1 more source

Effects of compositional heterogeneity and spatial autocorrelation on richness and diversity in simulated landscapes

open access: yesEcology and Evolution, 2023
Landscape structure plays a key role in mediating a variety of ecological processes affecting biodiversity patterns; however, its precise effects and the mechanisms underpinning them remain unclear.
Joseph Tardanico, Thomas Hovestadt
doaj   +1 more source

Wildlife friendly agriculture: which factors do really matter? A genetic study on field vole [PDF]

open access: yes, 2010
The distribution of genetic differentiation and the directions of gene flow were determined mainly by landscape factors: thus the expectation that organic fields act as genetic reservoir was not met.
Andersen, Liselotte Wesley   +5 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Land use changes of historical structures in the agricultural landscape at the local level — Hriňová case study

open access: yesEkológia (Bratislava), 2013
The aim of this paper is to describe agricultural landscapes in the cadastral area of Hriňova and their development in the context of social and economic changes over the past 60 years.
Mojses Matej, Petrovič František
doaj   +1 more source

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