Results 91 to 100 of about 327,471 (314)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Ekológia (Bratislava), 2013 The aim of this paper is to describe agricultural landscapes in the cadastral area of Hriňova and their development in the context of social and economic changes over the past 60 years.
Mojses Matej, Petrovič František
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Landscape relatedness: detecting contemporary fine-scale spatial structure in wild populations
, 2017 Methods for detecting contemporary, fine-scale population genetic structure in continuous populations are scarce.
Norman, Anita, +3 more
core +1 more source
On Structure of Experienced Landscape
Journal of the Japanese Institute of Landscape Architects, 1987 自由記述によるアンケート調査を実施し, 三つのキイワードによって記憶されている風景を喚起し, その内容を構造化して捉えた。「印象的な風景」は人間側 (体験) よりも対象側 (物理的要素, 空間) の軸が主要となる構造であること。「なつかしい風景」は風景のなかの自己体験が主要であり, 対象・人間ともに主要な軸となること。「いやな風景」は人間側が主要であり, かつ複雑な構造となっていることなどがわかった。
HORI, Shigeru +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The role of landscape structure in determining eco-evolutionary dynamics during environmental change [PDF]
, 2008 Climate change may produce a variety of responses in populations' ecological and evolutionary dynamics. At opposing limits of populations' ranges, the responses are expected to differ.
McInerny, Gregory John
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Applying Landscape Ecological Metrics on Land Use Change in Lanyang Plain [PDF]
Land use is the human activity affecting by economical, cultural, political and historical factors and presents complex, uncertainty and spatiotemporal characteristics.
Hsiao-Wen Wang
core