Results 111 to 120 of about 265,587 (266)

Multitemporal Analysis of Tree Cover, Fragmentation, Connectivity, and Climate in Coastal Watersheds of Oaxaca, Mexico

open access: yesLand
The synergistic interaction between landscape fragmentation and climate change poses a critical threat to tropical forests. However, the long-term dynamics of these coupled pressures have been little explored.
Manuel Juárez-Morales   +5 more
doaj   +1 more source

Effects of landscape structure on restoration success in tropical premontane forest. [PDF]

open access: yesSci Rep, 2022
San-José M   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Landscape structure affects the sunflower visiting frequency of insect pollinators. [PDF]

open access: yesSci Rep, 2021
Lajos K   +4 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

Estructura del paisaje a lo largo de gradientes urbano-rurales en la cuenca del río Aisén (Región de Aisén, Chile) Landscape structure along urban-rural gradients: Aisén river watershed (Aisén region, Chile)

open access: yesRevista Chilena de Historia Natural, 2009
Los cambios en la estructura del paisaje generalmente están asociados a factores físicos, biológicos y sociales. Sin embargo, su análisis integrado es poco frecuente.
MARCELA TORRES-GÓMEZ   +3 more
doaj  

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