Results 101 to 110 of about 16,161,426 (301)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Predicting a Prior for Planck

, 2014
The quantum state of the universe combined with the structure of the landscape potential implies a prior that specifies predictions for observations.
Hertog, Thomas
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Age-dependent decay in the landscape [PDF]

, 2007
The picture of the "multiverse" arising in diverse cosmological scenarios involves transitions between metastable vacuum states. It was pointed out by Krauss and Dent that the transition rates decrease at very late times, leading to a dependence of the ...
C. Kiefer, S. Winitzki, Sergei Winitzki
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Spatiotemporal Differentiation of Land Ecological Security and Optimization Based on GeoSOS-FLUS Model: A Case Study of the Yellow River Delta in China Toward Sustainability

Land
Land ecological security (LES) is a crucial issue pertaining to the sustainability of landscapes or land systems. Nevertheless, previous studies largely neglected the impacts of landscape structure on LES.
Lu Han, Yanbo Qu, Shufeng Liang, Luyan Shi, Min Zhang, Haiyan Jia   +5 more
doaj   +1 more source

Cellular Models for River Networks

, 2000
A cellular model introduced for the evolution of the fluvial landscape is revisited using extensive numerical and scaling analyses. The basic network shapes and their recurrence especially in the aggregation structure are then addressed.
A. D. Howard, A. Maritan, A. Rinaldo, A. Rinaldo, A. Rinaldo, A. Rinaldo, A.D. Howard, B. B. Mandelbrot, D.G. Tarboton, D.R. Montgomery, D.R. Montgomery, G. Caldarelli, G.R. Willgoose, Guido Caldarelli, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, J. Feder, J.T. Hack, K. Sinclair, L. Band, M. Marani, P. Bak, P. La Barbera, R. Rigon, R. Rigon, V. Sapozhnikov, W.E. Dietrich   +28 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Multitemporal Analysis of Tree Cover, Fragmentation, Connectivity, and Climate in Coastal Watersheds of Oaxaca, Mexico

Land
The synergistic interaction between landscape fragmentation and climate change poses a critical threat to tropical forests. However, the long-term dynamics of these coupled pressures have been little explored.
Manuel Juárez-Morales, Juan Regino-Maldonado, Juan José Von Thaden Ugalde, Fernando Gumeta-Gómez, Alfonso Vásquez-López, Jaime Ruíz-Vega   +5 more
doaj   +1 more source