Results 121 to 130 of about 2,063,143 (381)

Sampling from Rough Energy Landscapes [PDF]

open access: yes, 1905
We examine challenges to sampling from Boltzmann distributions associated with multiscale energy landscapes. The multiscale features, or "roughness," corresponds to highly oscillatory, but bounded, perturbations of a smooth landscape.
Plecháč, Petr, Simpson, Gideon
core   +4 more sources

The global procurement landscape of leishmaniasis medicines

open access: gold, 2021
Hye Lynn Choi   +4 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Complexity of evolutionary equilibria in static fitness landscapes [PDF]

open access: yes, 2013
A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reaching equilibrium only if a local ...
Kaznatcheev, Artem
core  

Soil Seed Banks and Their Relation to Soil Properties in Hilly Landscapes [PDF]

open access: gold, 2023
Regina Skuodienė   +2 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Landscape Analysis of Geographical Names in Hubei Province, China

open access: yesEntropy, 2014
Hubei Province is the hub of communications in central China, which directly determines its strategic position in the country’s development. Additionally, Hubei Province is well-known for its diverse landforms, including mountains, hills, mounds and ...
Xixi Chen   +5 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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