Results 81 to 90 of about 1,983,901 (377)

Characterizing Potentials by a Generalized Boltzmann Factor [PDF]

open access: yes, 2007
Based on the concept of a nonequilibrium steady state, we present a novel method to experimentally determine energy landscapes acting on colloidal systems.
C. Bechinger   +4 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Robotic 3DCP fabrication of custom-fit slabs for irregular pontoons

open access: yesArchitectural Intelligence
This paper presents a case study on the use of 3D concrete printing (3DCP) to qualify rocky pontoons with spaces for recreational use—namely sitting areas, circulation trails and fishing spots—and biodiversity protection—providing habitat and refuge for ...
João Ribeiro   +5 more
doaj   +1 more source

Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model

open access: yes, 2014
The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume   +3 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Paysages, implantation et architecture des monastères cisterciens entre Seine et Rhin du xiie au xviiie siècle

open access: yesLes Nouvelles de l’Archéologie, 2020
The Grand-Est region counted around 65 monasteries of the order of Cîteaux, founded between 1115 (Clairvaux) and before 1274 (Consolation). The presence of these abbeys and their barns, rural establishments attached to them, was a real marker of the ...
Benoit Rouzeau, Agnès Charignon
doaj   +1 more source

Landscapes of Production-Landscapes for Consumption [PDF]

open access: yesInternational Journal of Public and Private Perspectives on Healthcare, Culture, and the Environment, 2017
This paper is the second part of an exploration into the history and meaning of landscapes, based on a case study of the “must-see” scenic spots or Eight Views (bajing ??) of Linfen County in the south of China's Shanxi province. While the first part focused on the value of these iconic landscapes as sources of identity, here I will show how their ...
openaire   +2 more sources

Perception of native grasslands in south-eastern Australia: some implications for landscape aesthetics and other landscape values [PDF]

open access: yes, 2001
Grasslands are considered to be Australia’s most threatened ecosystems, yet relatively little is known about human preferences and attitudes which contribute to continued degradation of these landscapes.
Cary, John, Williams, Kathryn
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Communities of practice in landscapes of practice

open access: yesManagement Learning, 2019
The original formulation of communities of practice primarily focused on describing how learning, meaning, and identity within a community can translate into a sustained practice. Wenger-Trayner et al.
Igor Pyrko, Viktor Dörfler, C. Eden
semanticscholar   +1 more source

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