Results 101 to 110 of about 211,324 (292)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Meadow birds in Sweden – population trends, effects of restoration and management [PDF]

, 2010
The area of Swedish wet meadows has decreased drastically during the last century due to cultivation and abandonment. During the same time the meadow bird fauna have changed considerably.
Berg, Åke, Gustafson, Tomas
core  

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Utilizing symbiotic relationships and assisted migration in restoration to cope with multiple stressors, and the legacy of invasive species

Frontiers in Microbiomes
IntroductionClimate change has increased the need for forest restoration, but low planting success and limited availability of planting materials hamper these efforts. Invasive plants and their soil legacies can further reduce restoration success.
Lisa M. Markovchick, Lisa M. Markovchick, Abril Belgara-Andrew, Abril Belgara-Andrew, Duncan Richard, Tessa Deringer, Tessa Deringer, Kevin C. Grady, Kevin R. Hultine, Gerard J. Allan, Thomas G. Whitham, Thomas G. Whitham, José Ignacio Querejeta, Catherine A. Gehring, Catherine A. Gehring   +14 more
doaj   +1 more source

Landscape approaches for ecosystem management in Mediterranean Islands [PDF]

, 2012
This book presents a series of essays, drawing on the twm concepts of ecosystem management and landscape approaches, to elucidate and reflect on the present situation and future evolution of Mediterranean islands.
Baldacchino, Godfrey, Belkayali, Nur, Boissevain, Jeremy, Busuttil, Salvino, Camilleri, Alex, Cassar, Louis F., Chelazzi, Lorenzo, Colombini, Isabella, Conrad, Elisabeth, Cordina, Gordon, Farrugia, Nadia, Gallà, Damiano, Griffiths, Geoffrey H., Makhzoumi, Jala, Morse, Stephen, Phillips, Adrian, Priore, Riccardo, Roe, Maggie, Tazebay, Ilkden, Terkenli, Theano S., Vogiatzakis, Ioannis N., Çakci, Isil   +21 more
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Incorporating visual attention measures to reveal homeowners’ preferences for environmentally friendly urban landscapes

Journal of Urban Management
Sustainable urban planning practices can help reduce the urban heat island effect, promote green roofs and walls, and encourage the preservation of natural habitats within urban areas.
Xumin Zhang, Hayk Khachatryan
doaj   +1 more source

Building knowledge for Aboriginal and Torres Strait Islander remote tourism: lessons from comparable tourism initiatives around the world [PDF]

, 2013
This report aims to build knowledge about what issues Aboriginal and Torres Strait Islander people may need to consider in remote tourism by reviewing, compiling and drawing insights from comparable tourism initiatives around the world.The report is ...
Damien Jacobsen
core  

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Landscape Aesthetics of Check Dams Based on Scenic Beauty Estimation Method and Artificial Intelligence Technology

Engineering Proceedings
Check dams play a pivotal role in soil and water conservation engineering as they mitigate debris flow and decelerate the slope of the river channel by intercepting sediments, thereby preventing disasters.
Hong-Ming Weng, Szu-Hsien Peng, Chun-Yi Wu, Min-Chih Liang   +3 more
doaj   +1 more source