Results 131 to 140 of about 20,756 (247)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Beyond Suitability: Mapping Current and Projected Conservation Gaps for Three Rare Pheasants in Karst Landscapes of Southwest China. [PDF]

Animals (Basel)
Wu J, Yang J, Ran J, Wang Y, Li J, Zhu J, Zou J, Gou X, Luo H, Cheng S.   +9 more
europepmc   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

Beyond sightings: Ensemble modelling to identify conservation hotspots of Smooth-coated otters (Lutrogale perspicillata) in the Ganga River Basin for informed policy and sustainability. [PDF]

PLoS One
Hussain SA, Panda AK, Sharma SP, Shahniaz N, Barthwal S, Ali SZ, Badola R.   +6 more
europepmc   +1 more source

Redefining the Minimal Editable Unit of Supramolecular Synthons: A 1→2 Lattice‐Editing Strategy in Ternary Multicomponent Crystals

Advanced Science, EarlyView.
Inspired by skeletal editing, we propose a lattice‐editing strategy that extends the minimal editable unit in supramolecular crystals from individual components to local supramolecular structural units, enabling non‐stoichiometric one‐to‐many substitution while preserving the parent lattice architecture.
Zheng Lin, Honglei Xia, Min Li, Ruihui Wang, Ying Wang, Xiaoyu Feng, Mingjing Tang, Yuan Zhang, Qinghua Zhang   +8 more
wiley   +1 more source

Ecosystem Resilience and Land-Use Governance: Remote Sensing Insights for Environmental Management in a Tropical Dry Forest. [PDF]

Environ Manage
Nascimento da Silva L, Israel de Souza B.   +1 more
europepmc   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Multi-Scale Habitat Suitability and Spatial Distribution of the European Green Toad. [PDF]

Ecol Evol
Özçelik AE, Yıldırım RE, Altunışık A.   +2 more
europepmc   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

GIS-AHP-based land suitability assessment for sustainable agricultural planning on Qeshm Island. [PDF]

Sci Rep
Darvishi A, Yousefi M, Mousavi SM, Khoshnamvand H, Borhani F, Schirrmann M.   +5 more
europepmc   +1 more source