Results 71 to 80 of about 20,756 (247)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Spatial refuges buffer landscapes against homogenisation and degradation by large herbivore populations and facilitate vegetation heterogeneity

Koedoe: African Protected Area Conservation and Science, 2017
Environmental heterogeneity across savanna landscapes, including different seasonal resources at different distances to water, may play a critical role in maintaining the size and diversity of wildlife populations and the sustainability of their resource
Keoikantse Sianga, Mario van Telgen, Jip Vrooman, Richard W.S. Fynn, Frank van Langevelde   +4 more
doaj   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Utilizing symbiotic relationships and assisted migration in restoration to cope with multiple stressors, and the legacy of invasive species

Frontiers in Microbiomes
IntroductionClimate change has increased the need for forest restoration, but low planting success and limited availability of planting materials hamper these efforts. Invasive plants and their soil legacies can further reduce restoration success.
Lisa M. Markovchick, Lisa M. Markovchick, Abril Belgara-Andrew, Abril Belgara-Andrew, Duncan Richard, Tessa Deringer, Tessa Deringer, Kevin C. Grady, Kevin R. Hultine, Gerard J. Allan, Thomas G. Whitham, Thomas G. Whitham, José Ignacio Querejeta, Catherine A. Gehring, Catherine A. Gehring   +14 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

River continuum disruptions in a highly altered system: The perspective of potamodromous fish

Ecological Indicators
In this study, we explored how barriers such as dams have affected the longitudinal connectivity of riverine habitats from the perspective of potamodromous fish.
Johannes L. Kowal, Andrea Funk, Günther Unfer, Damiano Baldan, Gertrud Haidvogl, Christoph Hauer, Maria T. Ferreira, Paulo Branco, Rafaela Schinegger, Thomas Hein   +9 more
doaj   +1 more source

Protection of Karst in the Philippines

Acta Carsologica, 2006
The article presents an overview of the current status of karst protection in the Philippines. Prior studies indicate that of the 35,000km2 of karst landscape in the country, about 29% is protected .
Sonata Dulce F. Restificar, Michael J. Day, Peter B. Urich   +2 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Incorporating visual attention measures to reveal homeowners’ preferences for environmentally friendly urban landscapes

Journal of Urban Management
Sustainable urban planning practices can help reduce the urban heat island effect, promote green roofs and walls, and encourage the preservation of natural habitats within urban areas.
Xumin Zhang, Hayk Khachatryan
doaj   +1 more source

Water Systems as Cultural Landscapes: Conserving the Valens System and the Strandja Forests

International Journal of Conservation Science
Urban dependence on water has historically driven infrastructure development. In water-scarce Istanbul, the Valens Waterline, the longest Roman-period waterline, was constructed, sourcing water from the Strandja Forests. Today, this interconnected system is at risk: while the Strandja Forests are under intense pressure, the water system is only ...
Örnek, Elif, Yalçin, Berfin Gönül
openaire   +2 more sources