Results 81 to 90 of about 133,759 (309)
Future information environments: deserts, jungles or parks? [PDF]
, 2006 This paper discusses the basic functions of a common information environment and how they are supported by metadata. Several distinct categories of information landscapes are described, characterised by the availability and quality of metadata at the ...
Dunsire, Gordon
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
International Documents on Landscape Restoration
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2015 In the theory and practice of cultural monuments protection, including garden art monuments and landscape protection, it has been often referred to international conventions and other international documents relating to this protection.
Olga Pouperová +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Ecological consequences of the playgrounds' reconstruction of specialized "park-stadium Khimmash", in Yekaterinburg [PDF]
, 2019 In connection with the World Cup in 2018 in the Russian Federation, including the qualifying matches of the World Championship in Yekaterinburg, the Government of the Sverdlovsk Regiondecided to place a training ground on the territory of the "Park ...
Atkina, L. I. +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Advances in Horticultural ScienceGrowers in tropical and subtropical climates with higher afternoon solar intensities face challenges while cultivating potted dahlias. Dahlias that are cultivated in pots with limited capacity lose a great deal of their quality when it gets hot outside.
Simrat Singh, Aradhna
doaj +1 more source
Wetland Buffer Characterization and Public Outreach in North Hampton [PDF]
, 2008 This report includes a characterization of wetland buffers and buffer protection in North Hampton and a community outreach newsletter that focuses on the protection of the North Hampton wetland buffers.
Kellam, Dave
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source