Results 101 to 110 of about 133,759 (309)
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
Barriers to English Language Learners in the Chicago Metropolitan Area [PDF]
, 2001 Immigrants from all over the world are continuing to move to Illinois in large numbers. As they settle into an increasingly diverse range of communities within metropolitan Chicago, this expansion of ports of entry creates new challenges for the state ...
Jody Raphael, Lise McKean, Melissa Ford
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Landscaping with fluxes and the E8 Yukawa Point in F-theory [PDF]
, 2014 Integrality in the Hodge theory of Calabi-Yau fourfolds is essential to find the vacuum structure and the anomaly cancellation mechanism of four dimensional F-theory compactifications.
Bizet, Nana Cabo +2 more
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The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
PUSH Buffalo\u27s Community Housing Co-operative: A Case Study in Green Building Rehabilitation [PDF]
, 2017 Between March 2006 and March 2007, a group of community organizers at People United for Sustainable Housing (PUSH) used green building methods to create affordable, safe, and sustainable housing by rehabilitating a formerly abandoned four unit building ...
O\u27Donnell, Mary
core +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Communities in Action. The Handbook [PDF]
, 2003 Focuses on ways to enable and improve the practice of participatory design, urban design and neighbourhood ...
Frey, H.W., Romice, O.R.
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