Results 91 to 100 of about 16,249 (258)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2008 MC022A new real estate development in an old neighborhood uses the adjacent stream for its common ...
Craig Denton
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BMC Plant BiologyBackground Reuse of treated wastewater is a long-standing yet increasingly vital approach to alleviating water scarcity challenges in agricultural development.
Mehdi Nasirpour +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Morphophenological characterization of ornamental ginger and selection for landscape use
Ornamental Horticulture, 2018 Many species of Zingiber have great ornamental potential, due to durability and exotic appearance of the inflorescences. Despite its large phenotypic variability, they are scarcely exploited or not yet exploited regarding the ornamental potential.
Carlos Eduardo Ferreira de Castro +3 more
doaj +1 more source
LANDSCAPE AND VIDEOART: THE NEW LANDSCAPE OF THE ANTHROPOCENE.
SGEM International Multidisciplinary Scientific Conferences on SOCIAL SCIENCES and ARTS Proceedings, 2019 We live in a new era -the Anthropocene-. And in a new society with its corresponding mentality and consciousness. But, we keep representing and interpreting the landscape, mainly, through the codes inherited from the Romanticism. This research will address artistic proposals that unite videoart and landscape.
openaire +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2008 Revised! ENH-971, a 3-page fact sheet by Eva C. Worden and Sydney Park Brown, describes a landscaping practice that replaces plants that are strictly ornamental with plants that produce food.
Sydney Park Brown, Eva C. Worden
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