Results 161 to 170 of about 6,181,214 (306)

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

open access: yesAdvanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin   +14 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

open access: yesAdvanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu   +10 more
wiley   +1 more source

Detection of Lane-Change Events in Naturalistic Driving Videos. [PDF]

open access: yesIntern J Pattern Recognit Artif Intell, 2018
Wang S, Ott BR, Luo G.
europepmc   +1 more source

Examining Lois Lane The Scoop on Superman's Sweetheart

open access: yes
This collection of essays examines the Lois Lane character in comic books, film, and television to address various aspects of sexuality, gender, social change, and feminism.Intro -- Title Page -- Acknowledgments -- Introduction -- Full Disclosure -- The ...
Farghaly, Nadine.
core  

Lane County Notice of Adopted Amendment (2010-08-27)

open access: yes, 2010
358 pp. Adopted 2010-08-27. Department of Land Conservation and Development Notice of Adopted AmendmentAmending Lane Code Chapters 13, 14, & 16 to add and revise definitions and other provisions to be consistent with the ORS and OAR and to make ...
Lane County (Or.)
core  

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

open access: yesAdvanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park   +13 more
wiley   +1 more source

Design for office desk : sketch no. 35 [picture] /

open access: yes, 1926
Part of collection: Furniture designs for Prime Minister's Lodge and Government House, Canberra.; Inscriptions: signed "Ruth Lane-Poole, 14/10/26" -- in ink.; Condition: vertical tear in the middle of the drawing.; Also available in an electronic version
Lane Poole, Ruth, 1885-1974.
core  

Diverging Liquid–Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins

open access: yesAdvanced Science, EarlyView.
Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Tim Schiller   +2 more
wiley   +1 more source

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