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Langerhans’ Cell Histiocytosis
Orthopedic Clinics of North America, 1996Langerhans' Cell Histiocytosis, formerly known as Histiocytosis X, and its related syndromes (i.e., eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease) are briefly reviewed. The biology, clinical manifestations, and treatment options of the localized, single form and the disseminated, multisystem form are also discussed.
Maria C. Velez-Yanguas, Raj Warrier
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Skeletal Radiology, 2006
Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems and, most typically, the skull ...
Kevin B. Hoover +2 more
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Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems and, most typically, the skull ...
Kevin B. Hoover +2 more
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The Journal of Pediatrics, 1995
The first major stride toward understanding LCH was taken when ultrastructural studies identified the proliferating cells as part of the Langerhans (dendritic) cell system. Another step forward was the definition of the morphologic, immunohistochemical, and clinical criteria needed for the diagnosis of LCH.
R. Maarten Egeler, Giulio J. D'Angio
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The first major stride toward understanding LCH was taken when ultrastructural studies identified the proliferating cells as part of the Langerhans (dendritic) cell system. Another step forward was the definition of the morphologic, immunohistochemical, and clinical criteria needed for the diagnosis of LCH.
R. Maarten Egeler, Giulio J. D'Angio
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Journal of Cutaneous Medicine and Surgery, 2012
Background: The cutaneous presentation of Langerhans cell histiocytosis (LCH) is very rare and can be highly variable among individuals, which can often lead to a delay in diagnosis. Objective: To discuss a case report and literature review of important clinical indicators, histology, diagnosis, evaluation, and treatment guidelines.
Clayton Schiltz +2 more
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Background: The cutaneous presentation of Langerhans cell histiocytosis (LCH) is very rare and can be highly variable among individuals, which can often lead to a delay in diagnosis. Objective: To discuss a case report and literature review of important clinical indicators, histology, diagnosis, evaluation, and treatment guidelines.
Clayton Schiltz +2 more
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Archives of Disease in Childhood, 2009
Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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New England Journal of Medicine, 1987
Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"1 later considered to be the first case of the Hand-Schul1er–Christian syndrome.
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Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"1 later considered to be the first case of the Hand-Schul1er–Christian syndrome.
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THE EPIDEMIOLOGY OF LANGERHANS CELL HISTIOCYTOSIS
Hematology/Oncology Clinics of North America, 1998Little progress has been made in finding the causes of LCH. Epidemiologic studies are difficult because of the rarity of this disease. Although several associations have been demonstrated in case-control studies, particularly that with thyroid disease, no causal relationships have been documented. Additional case-control studies may uncover the to-date
R. Maarten Egeler +2 more
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Langerhans cell histiocytosis in the adult
Medical and Pediatric Oncology, 1996A study of 47 well-documented patients with Langerhans cell histiocytosis (LCH) showed a slight female preponderance, with onset as late as the ninth decade. The skin was the commonest site of presentation, but pulmonary and bone involvement was frequent. Patients with single-site disease did best.
Andrew J. Norton, J. S. Malpas
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Langerhans' cells histiocytosis.
International journal of pediatric otorhinolaryngology, 1999Langerhans cell histiocytosis (LCH) is a rare disorder of unknown cause, characterized by the proliferation of histiocytic cells in various tissues and organs. The role of the otolaryngologist is important in the early and accurate evaluation, staging and diagnosis of LCH, because it may mimic more common diseases such as otitis externa and acute ...
SELLARI FRANCESCHINI, STEFANO +5 more
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