Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom [PDF]
British Journal of Haematology, Volume 209, Issue 2, Page 747-754, August 2026.Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Rodothea Amerikanou +15 more
wiley +2 more sources
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis [PDF]
Journal of Clinical and Experimental Hematopathology, 2016 Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as LCS is more likely by recent studies, a category of LC hyperplasia can ...
Nakamine, Hirokazu +5 more
openaire +4 more sources
An Overlap of Erdheim–Chester Disease and Rosai–Dorfman Disease With Isolated Bone Lesions Presenting a Diagnostic Challenge: A Case Report [PDF]
Clinical Case Reports, Volume 14, Issue 10, October 2026.ABSTRACT Some of the rarest diseases with cell accumulation in different organs are histiocytoses. Since these diagnoses are uncommon, other differential diagnoses must be excluded. We report a case of a 42‐year‐old man with episodes of knee pain and fever.
Maris Tulk +4 more
wiley +2 more sources
Prolonged remission with pembrolizumab and radiation therapy in a patient with multisystem Langerhans cell sarcoma [PDF]
Haematologica, 2022 Saurabh Zanwar +7 more
doaj +2 more sources
Langerhan's Cell Sarcoma: Two Case Reports [PDF]
Rare Tumors, 2016 Langerhan's cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases.
Tasneem A. Kaleem +6 more
openaire +3 more sources
Multifocal Langerhans cell histiocytosis in a child
Radiology Case Reports, 2021 Langerhans Cell Histiocytosis (LCH) is a rare disorder sometimes called the disorder of the “monocyte-macrophage system”. This condition is characterized by the proliferation of abnormal Langerhans cells within different tissues. Skin rash is the typical
Juna Musa, MD, MSc +11 more
doaj +1 more source
Retroperitoneal Erdheim-Chester disease without skeletal bone involvement mimicking uterine sarcoma with multiple organ involvement [PDF]
Obstetrics & Gynecology Science, 2020 Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis and is characterized by the diffuse histiocytic infiltration of multiple organs. Retroperitoneal ECD, especially with uterine involvement, is extremely rare.
Hae Min Kim +4 more
doaj +1 more source
Langerhans cell histiocytosis [PDF]
, 2020 Tumours derived from Langerhans cells (LCs) are divided into two main subgroups, according to the degree of cytological atypia and clinical aggressiveness: LC histiocytosis (LCH) and LC sarcoma.
Chen, Ding-Bao
core +1 more source
Langerhans Cell Sarcoma Arising from Langerhans Cell Histiocytosis: A Case Report [PDF]
Journal of Korean Medical Science, 2006 Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that have overtly malignant cytologic features. It is a very rare disease and theoretically, it can present de novo or progress from an antecedent Langerhans cell histiocytosis (LCH). However, to our knowledge, LCS arising from an antecedent LCH has not been reported on. We
Lee, Jong-Sil +5 more
openaire +2 more sources
Interdigitating dendritic cell sarcoma: case report and literature review
Клиническая онкогематология, 2013 We present the literature data and the authors’ observation of interdigitating dendritic cell sarcoma (IDCS), a very rare tumor consisting of histiocytic and dendritic cells.
P. A. Zejnalova +3 more
doaj +1 more source