Results 51 to 60 of about 6,014,143 (193)

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells [PDF]

, 2012
We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis ...
Dittmann, Kai, Ridzewski, Rosalie, Diana Marklein (105976), Albert Rosenberger (28881), Diana Marklein, Kai Dittmann (105997), Simone Fulda, Rosalie Ridzewski, Jürgen Wienands, Ulrike Graab, Wienands, Juergen, Simone Fulda (106002), Graab, Ulrike, Frauke Nitzki, Nitzki, Frauke, Rosenberger, Albert, Tiandong Yan, Kai Dittmann, Yan, Tiandong, Yan, T., Heidi Hahn (106003), Naumann, Ivonne, Heidi Hahn, Fulda, Simone, Ivonne Naumann, Wienands, Jürgen, Ivonne Naumann (105981), Leszek Wojnowski (106001), Wojnowski, Leszek, Marklein, Diana, Ulrike Graab (105978), Tiandong Yan (105985), Jürgen Wienands (105999), Hahn, Heidi, Albert Rosenberger, Frauke Nitzki (105993), Leszek Wojnowski, Rosalie Ridzewski (105989), Fulda Simone, Ridzewski Rosalie, Marklein Diana, Wojnowski Leszek, Rosenberger Albert, Yan Tiandong, Hahn Heidi, Wienands Jürgen, Nitzki Frauke, Dittmann Kai, Graab Ulrike, Naumann Ivonne   +49 more
core   +1 more source

PEMBROLIZUMAB PLUS RADIOTHERAPY AS A RESCUE THERAPY FOR LANGERHANS CELL SARCOMA: A CASE REPORT

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Langerhans Cell Sarcoma (LCS) is an aggressive and extremely rare form of malignant histiocytosis, with a dismal prognosis. Case report: A 62-year-old male with mild comorbidities (overweight, hypertension, type 2 DM and NAFLD) presented ...
JM Nascimento, AAGS Brandão, ANR Abdo, XLM Serafim, EL Diamond   +4 more
doaj   +1 more source

Nodal Langerhans cell neoplasm: detailing the diagnostic quandaries

, 2021
Langerhans cells, found in the supra-basal region of the mucous membranes in the epidermis of the skin, in lymph nodes and thymus, function as antigen-presenting cells within the histiocyte system. Tumors derived from Langerhans cells (LC) can be divided
Khaddar, Satvik, Chowdhury, Zachariah, Varshney, Juhi, Singh, Anil, Satvik Khaddar, Zachariah Chowdhury, Anil Singh, Juhi Varshney   +7 more
core   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Diagnostic Utility of p16 and MTAP Immunohistochemistry for Cellular Neurothekeomas

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Aims Cellular neurothekeoma (cNTK) is a benign cutaneous tumor of uncertain histogenesis. Recent genomic characterization identified recurrent deletions on chromosome 9p21.3, encompassing CDKN2A (p16), as a primary driver event in cNTK. We assessed the potential utility of p16 and MTAP immunohistochemistry for discriminating cNTKs from ...
Joseph S. Durgin, Katharina Wiedemeyer, Grace Wang, Scott C. Bresler, Steven M. Hrycaj, Louise van der Weyden, David J. Adams, Thomas Brenn, Paul W. Harms   +8 more
wiley   +1 more source

An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]

, 2016
We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Boffa, Michael J., Baldacchino, Godfrey, Gatt, Alexander, Betts, Alexandra   +3 more
core  

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma

Clinical Pathology, 2019
We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient presented in 2017 with painful, enlarging swelling of the left neck.
Stephanie L Skala, Jing C Ye, Jennifer Stumph, William R Macon, Frances R Quinones, Vadim Khachaturov, Rhett P Ketterling, Rajan Dewar   +7 more
doaj   +1 more source

Differential Diagnosis Performance of ChatGPT in Oral and Maxillofacial Pathology

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate ChatGPT (GPT‐5.1) for ranked differential diagnoses in oral and maxillofacial pathology, assess image effects on diagnostic performance and examine output stability across repeated runs. Methods This retrospective diagnostic accuracy study included 160 biopsy‐confirmed cases.
Sohaib Shujaat, Marryam Riaz, Jawaher Mohammed Alsubaie, Aljwhrah Abdulaziz Almuammar, Arun Pillai, Abdulmohsen Alfadley, Ali Anwar Aboalela   +6 more
wiley   +1 more source

Langerhans cell sarcoma: a case report and review of the literature [PDF]

Polish Journal of Pathology, 2016
We present the case of a 62-year-old male patient with a three-month history of pain in the left shoulder. Magnetic resonance imaging of the left scapula showed an osteo-destructive lesion. H&E stained sections revealed a Langerhans cell sarcoma, and immunohistochemistry was performed additionally; CD68, CD163, CD14, fascin, HLA-DR, lysozyme, S100 ...
D T, Liu, J, Friesenbichler, L A, Holzer, B, Liegl-Atzwanger, C, Beham-Schmid, A, Leithner   +5 more
openaire   +2 more sources