Results 61 to 70 of about 4,143,501 (310)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Developmental Constraints on Learning Artificial Grammars with Fixed, Flexible and Free Word Order

Frontiers in Psychology, 2017
Human learning, although highly flexible and efficient, is constrained in ways that facilitate or impede the acquisition of certain systems of information.
Iga Nowak, Iga Nowak, Giosuè Baggio, Giosuè Baggio   +3 more
doaj   +1 more source

Understanding the Process of Second Language Acquisition [PDF]

, 2021
Yixu Ding
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Coherence Between Brain Activation and Speech Envelope at Word and Sentence Levels Showed Age-Related Differences in Low Frequency Bands

Neurobiology of Language, 2021
Speech perception is dynamic and shows changes across development. In parallel, functional differences in brain development over time have been well documented and these differences may interact with changes in speech perception during infancy and ...
Orsolya B. Kolozsvári, Weiyong Xu, Georgia Gerike, Tiina Parviainen, Lea Nieminen, Aude Noiray, Jarmo A. Hämäläinen   +6 more
doaj   +1 more source

The ubiquity of frequency effects in first language acquisition

Journal of Child Language, 2015
This review article presents evidence for the claim that frequency effects are pervasive in children's first language acquisition, and hence constitute a phenomenon that any successful account must explain.
Ben Ambridge, E. Kidd, C. Rowland, Anna L. Theakston   +3 more
semanticscholar   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Analyzing Complex Longitudinal Data in Educational Research: A Demonstration With Project English Language and Literacy Acquisition (ELLA) Data Using xxM

Frontiers in Psychology, 2018
When analyzing complex longitudinal data, especially data from different educational settings, researchers generally focus only on the mean part (i.e., the regression coefficients), ignoring the equally important random part (i.e., the random effect ...
Oi-Man Kwok, Oi-Man Kwok, Mark Hok-Chio Lai, Fuhui Tong, Fuhui Tong, Rafael Lara-Alecio, Rafael Lara-Alecio, Beverly Irby, Beverly Irby, Beverly Irby, Myeongsun Yoon, Myeongsun Yoon, Yu-Chen Yeh   +12 more
doaj   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source