Results 61 to 70 of about 1,625,474 (306)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Correction of Some Words in the Divan of Suzani Samarqandi [PDF]
متن شناسی ادب فارسیSuzani Samarqandi is a skillful poet who, despite his merit, has not received sufficient scholarly attention, neither himself nor his poetry. Among the main reasons for this neglect are the difficulties of the language of his poetry and the lack of old ...
Faezeh Ghouchi, Ali Rahimi varyani
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Indonesian Journal of Applied LinguisticsCurrently, a large number of ethnic languages worldwide are losing their vitality and popularity due to globalization and the influence of dominant languages such as English and Indonesian.
Dingding Haerudin +3 more
doaj +1 more source
The Correction of Two Mistakes in the Biography of Mohammad Hossein Hosseini-e Shirazi, Poet and Mystic in Qajar Era [PDF]
تاریخ ادبیاتIntroductionThe effort of researchers in biography writing has led to a better knowledge of poets’ lives and works, but sometimes there are mistakes in the information. Therefore, it is necessary to review them to create a secure foundation by correcting
Masume Sadeqi +2 more
doaj +1 more source
Coursebook authors on the role of literature in developing intercultural competence
, 2021 This paper focuses on Finnish English language textbook authors' understanding of the role of literature in the development of upper secondary school English students' intercultural competence.
Luukka, Emilia
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Criticism and correction of some verses from the sixth book of Shahnameh published by Khaleghi Mutlaq [PDF]
پژوهشهای نسخه شناسی و تصحیح متونJalal Khaleghi mutlaq has made an exhausting effort in correcting Ferdowsi's Shahnameh, but by recording all the altered versions in the footnotes he has exposed the critical text of the Shahnameh to the criticism and assessment of researchers in the ...
dariush ghale ghobadi, teymoor malmir
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source