Results 81 to 90 of about 801,535 (310)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Spatial Skills First: The Importance of Mental Rotation for Arithmetic Skill Acquisition
Journal of Numerical Cognition, 2019 Considering the importance of arithmetic in school curricula, it is crucial to understand the cognitive processes underlying its successful acquisition.
Carrie Georges +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Using evaluation to promote change in language teacher practice
, 2016 Recent literature in teacher education has argued for a shift away from the development of teacher cognitions as a goal of teacher education, to the development of core practices which would make a difference to students’ lives in the classroom (Ball ...
Erlam, Rosemary
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Theory and Practice of Second Language AcquisitionPrevious research has established that determining lexical sophistication (i.e., the percentage of sophisticated words in a text) through the judgment of teachers on a corpus of words is a more accurate method than relying on word frequency-based lists.
Eihab Abu-Rabiah
doaj +1 more source
Journal of Numerical Cognition, 2017 Evidence for number-space associations in implicit and explicit magnitude processing tasks comes from the parity and magnitude SNARC effect respectively.
Carrie Georges +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Finding out What Learners Know – and...? Reflections on Teachers' Language Assessment Literacy
, 2020 The current text focuses on assessment as an obvious aspect of [language] education, inseparable from learning and teaching. Together, the three concepts form a pedagogical trinity, fundamental to language teachers’ professional competence.
Erickson, Gudrun,
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The Alternatives in Language Assessment: Advantages and Disadvantages [PDF]
, 1998 Language testing is different from testing in other content areas because language teachers have more choices to make than teachers of other subject matter.
Brown, James Dean, Hudson, Thom
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