Results 81 to 90 of about 783,160 (287)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Comparative Perspective on Language Shift and Language Change: Norwegian and German Heritage Varieties in North America

Languages
This study evaluates the relationship between language shift and linguistic change in multigenerational immigrant communities, focusing on North American Norwegian (NAmNo) and German heritage varieties.
Alexander K. Lykke, Maike H. Rocker
doaj   +1 more source

Mudança linguística no modo imperativo – uma análise multissistêmica

Filologia e Linguística Portuguesa, 2011
From a corpus made up of dramatic texts produced in Brazil’s southeast region between 1850 and 1975, our research aims to study speakers’ usage of the imperative mood in the singular form during this period of time. Our intention was to investigate usage
Henrique Santos Braga
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Does you mean I?

Norsk Lingvistisk Tidsskrift, 2017
In Swedish today, du (‘you’) is sometimes used with generic reference. This use of generic du is often claimed to be a new invention, triggered by English influence in the late 20th century. However, in this article an analy­sis of occurrences of du from
Sanna Skärlund
doaj  

Semantic English Influence on Danish since 1700

RiCognizioni
Ever since the French anglomanie in the 18th century, a major part of the impact of English on recipient languages has been invisible – in the sense that the borrowed words, phrases and structures do not display any visible English clues.
Henrik Gottlieb
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Probleemkohti tänapäeva eesti keele vormimoodustuses

Keel ja Kirjandus
Issues in Modern Estonian morphology This article discusses various aspects of the description of Modern Estonian morphology in dictionaries published by the Institute of the Estonian Language. The rich system of declension and conjugation in Estonian,
Maire Raadik, Ülle Viks, Indrek Hein, Jelena Kallas   +3 more
doaj   +1 more source

Reply to Sun: Making sense of language change. [PDF]

Proc Natl Acad Sci U S A, 2022
Scheffer M, van de Leemput I, Weinans E, Bollen J.   +3 more
europepmc   +1 more source