Results 71 to 80 of about 4,120,923 (300)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Peculiarities of Metathesis in Kunha Language

open access: yesArbitrer
This paper focuses on metathesis, a linguistic phenomenon observed in the unique language called Kunha, a part of the North-Dravidian language family, where sounds are swapped within words. So, instead of the anticipated order of ..xy.. in a sequence of
Anup Kumar Kujur, Biswanandan Dash
doaj   +1 more source

La toponymie orale comme témoignage d’une langue éteinte

open access: yesLa Bretagne Linguistique, 1987
It has been said that an extinct language still lives on in toponymy: we were thinking then of written toponymy which, it is true, is enough to give a colour, an aura to a region when it is very general, for example Cornwall or south-east Wales, where ...
Pierre Flatrès
doaj   +1 more source

Christianity, language contact and language change [PDF]

open access: yes, 2017
In this paper, I argued that conversion to Christianity and Christian practice provide a context for linguistic contact between the vernacular language of the converted population and the ecclesiastic language. This contact, as any other language contact,
Khachaturyan, Maria
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Coded Language: The History, the Message, and 2016 [PDF]

open access: yes, 2017
How do politicians, particularly presidential candidates, talk about race without talking about race? Since the 1960s, race baiting in American politics has gone increasingly underground into the realm of coded language and dog-whistle rhetoric; that ...
Bruno, Adam
core   +2 more sources

Editorial [PDF]

open access: yes, 2008
An introduction to the journal is presented in which the author discusses several articles including those on today's teaching and learning of language and music, Sylvia Ashton-Warner's contribution to educational theory and classroom pedagogy and ...
De Luca, Rosemary
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

A Comparative Perspective on Language Shift and Language Change: Norwegian and German Heritage Varieties in North America

open access: yesLanguages
This study evaluates the relationship between language shift and linguistic change in multigenerational immigrant communities, focusing on North American Norwegian (NAmNo) and German heritage varieties.
Alexander K. Lykke, Maike H. Rocker
doaj   +1 more source

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