Results 81 to 90 of about 209,516 (359)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Towards a Formal Composition Language
, 1997 When do we call a software development environment a composition environment? A composition environment must be built of three parts: i) a reusable component library, ii) a component framework determining the software architecture, and iii) an open and ...
Franz Achermann +8 more
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Document Flow Model: A Formal Notation for Modelling Asynchronous Web Services Composition
, 2005 This paper presents a formal notation for modelling asynchronous web services composition, using context and coordination mechanisms. Our notation specifies the messages that can be handled by different web services, and describes a system of inter ...
Cirstea, Corina +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The development of language abilities in elementary school children
, 1964 The previous four reports [Reports 7, 10, 14, 17] were, so to speak, interim reports issued during our survey of the development of language ability. This book is a collection of the above data, rearranged in order to see the development afresh and as a ...
The National Language Research Institute +4 more
core +1 more source
Situation aspect as a universal aspect : implications for artificial languages [PDF]
, 2002 Aspect, as one of the elements of verb mechanics, has been overlooked by many language designers. This paper argues that an artificial language, designed as a universal language for international communication, should incorporate the "universal ...
Anthony McEnery +3 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Lookback supports semi-parallel, just-in-time processing in second language written composition.
PLoS ONEPurposeCompetent written production results from semi-parallel processes that flow from content determination to finger movement. Information from upstream processes that is not used immediately is easily lost.
Evgeny Chukharev +2 more
doaj +2 more sources
The Journal of Classics TeachingThis research aims to explore the ways in which creative writing may be used as a pedagogical tool in the Latin language classroom, in particular how creative writing may benefit students in Latin prose composition.
Emily Romain
doaj +1 more source
A Formal Language for Composition
, 2000 A composition language based on a formal semantic foundation will facilitate precise specification of glue abstractions and compositions, and will support reasoning about their behaviour.
Achermann, Franz +2 more
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