Results 111 to 120 of about 1,301,693 (307)
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The development of language abilities in elementary school children
, 1964 The previous four reports [Reports 7, 10, 14, 17] were, so to speak, interim reports issued during our survey of the development of language ability. This book is a collection of the above data, rearranged in order to see the development afresh and as a ...
The National Language Research Institute +4 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Language development and development of language: The case of Indonesia
, 2015 Contents iiiPREFACE vCHAPTER 1: REDEFINITIONS 1 1.1 Introduction 1 1.2 Studying language and development 2 1.3 Developing language, languaging development 5CHAPTER 2: Pembangunan 8 2.1 Keyword 8 2.2 Biography 11 2.3 Significant others 19 2.3.1 Pancasila 20 2.3.2 Perkembangan 21 2.4 Exogenous challenge, endogenous response 23CHAPTER 3: LANGUAGE OF ...
openaire +2 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Language policy and nation-building in post-apartheid South Africa.
, 2007 PhDWhile not essential, the link between language and national identity is nevertheless often a highly important and salient one, a fact illustrated by the centrality of linguistic concerns in many nationalist discourses throughout the world.
Orman, J, Orman, Jon., Orman, Jon
core +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Language Development and Acquisition in Early Childhood
, 2019 The paper focuses on the process of language development and acquisition in early child-hood and it gives a brief overview of the theories of language development The paper then concludes with an explanation of the importance of overexposure for early ...
Salwa Alharbi
core