Results 91 to 100 of about 1,301,693 (307)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Power and marginalization in discourse on AI in education (AIEd): social actors’ representation in China Daily (2018–2023)

open access: yesHumanities & Social Sciences Communications
Artificial Intelligence in Education (AIEd) has the potential to transform educational practice, and its media representation both reflects and reshapes public perceptions of this new technology.
Xi Huang, Savitri Gadavanij
doaj   +1 more source

Bilingual first language acquisition: the nature of the weak language and the role of the input [PDF]

open access: yes, 2011
This thesis investigates the development of the weak language in early bilingual language acquisition and its results are based on longitudinal and experimental data from 4 Italian-English bilingual children and their parents.
La Morgia, Francesca
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Language Development Research, Teaching, and Learning: A Cross-field Perspective [PDF]

open access: yes
This reflective piece seeks to shed light on the numerous contributions of Diane Larsen-Freeman to theory construction, applied linguistics, and language education by drawing parallels and insights from the FIFA 2022 Qatar World Cup Final. Looking at the
Elka Todeva
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Individual Differences in Global Cognition Modulate the Effect of Motor-Relatedness on Object Naming in Healthy Older Adults

open access: yesBehavioral Sciences
Lexical retrieval difficulty is a common daily complaint among older adults. Recent evidence suggests that older adults name motor-related nouns (e.g., knife) more accurately than non-motor nouns (e.g., steak).
Yang Xiao, Yanping Dong
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

An Integrated Approach to Using Literature to Learn Language (L3): A Guideline for Language Teachers [PDF]

open access: yes
Although formerly a cornerstone of language learning, literature became less popular with the rise of communicative language teaching, which prioritizes interaction.
Carol Griffiths
core   +1 more source

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